Abstract
The phosphorescence properties, especially, their dynamic behavior of metal free and metal complexed porphyrins have been studied in saline containing 0 - 3 % human serum albumin(HSA). 6,7-Bisaspartyl-2,4-bis (1-hexyloxyethyl)-deutero-porphyrin (DP) and its galium (III) complex (Ga-DP), zinc (II) complex (Zn-DP), and indium (III) complex (In-DP) are used as photosensitizers.
In this paper, chemiluninescenc (CL) caused by photosensitization of porphyrins has been reported first time. Solution of porphyrins containing HSA more than 0.1 % upon irradiation cones to shots the phosphorescence tai th a lifetime longer than 1 ms of porphyrins concerned. with the increase in the irradiation time, the phosphorescence intensities and triplet lifetimes of porphyrins increase, depending upon their concentrations and triplet lifetimes and approach the saturated values close to those under deaerated conditions. The experimental results for phosphorescence and chemiluminescence may be interpreted in terms of anoxia in local environments surrounding the sensitizer induced by photosensitization. The cause of anoxia can be attributed to the reaction between serum proteins and singlet molecular oxygen generated by photosensitization of porphyrins.
