Abstract
We have investigated the effects of local hyperthermia using Nd: YAG laser and shortwave radiofrequency. Groups of C3H/He mice transplanted tumors (Dunn osteosarcoma) were treated with local hyperthermia. Heating was performed for 15 minutes in laserthermia and 60 minutes in radiofrequency. After the treatment with each heating systems at 42.5-43°C, animals were subsequently sacrificed at 3 and 7 days. We observed the pathohistological and electron microscopical changes in the tumor cells and tissue. In spite of using different heating systems and treating different heating time, almost same tumor destructive changes were observed. These results suggest that hyperthermia is one of the effective treatment methods for osteosarcoma and in addition to heat, Nd: YAG laser energy may have another effect.
