Abstract
Recently, sulphonated aluminum chloro phthalocyanine (AIPC) has attracted a great deal of attention as a new photosensitizer in photodynamic therapy (PDT). Tissue concentrations and photodynamic effects of AIPC and hematoporphyrin derivative (HpD), that has been using clinically in PDT, were determined in nude mice transplanted bladder tumors. Photodynamic effect with AIPC and light (light emission at 675nm from the titanium-sapphire laser) were compared with that of HpD and laser light at 630nm. According to the tissue distribution of AIPC and HpD at various times after administration, the ratios of tumoral concentration to muscular concentration of AIPC were higher than those of HpD, and skin concentration of AIPC at 24 to 168 hr after administration was lower than that of HpD, These results suggest that more selectively AIPC localizes in malignant tumor than HpD, and there is a possibility of reducing skin photosensitivity with AIPC as compared with HpD. The regression of tumor volume after PDT was higher with AIPC than with HpD.
These results suggest that AIPC may be promising photosensitizer for PDT in respect of the selective tumor destruction and the reducing skin photosensitivity.
