1993 Volume 14 Issue Supplement Pages 445-448
The authors have evaluated the possibility of tetracycline derivatives-doxycycline (DC), minocycline (MINO), oxytetracycline (OTC), rolitetracycline phosphate (NPRMTC), and rolitetracycline (PRMTC) as the photosensitizer for PDT. Exicitation source used is third harmonic beam (355nm) of a Nd; YAG laser. The evaluation of intensity ratio indicated that DC had the best selectivity for the atheromatous plaque.
In order to define the acceptable laser power for PDT, we examined previously the acute efect of laser irradiation to resected plaques that induced rabitts' abdominal aorta treated with or without those photosensitizer. The laser was radiated in the power of 0.5, 1, 2, 3, or 6W/cm2, and the effects was evaluated as “vapolization time”. Based on this result, we decided to try the PDT to the rabbits models with degree of the power without acute effect. In result, the effect of PDT at two month follow up indicated DC was the most effective photosensitizer for PDT. Atheromatous plaque was disappeared without acute damage. DC was thought to be one of the useful drug as the photosensitizer for PDT of atherosclerosis.
