1996 Volume 17 Issue Supplement Pages 91-94
We have previously reported our tremedous results from phtodynamic therapy (PDT) for superficial squamous cell carcinoma of the esophagus. Patients with five submucosal and fifteen mucosal carcinoma recieved PDT from 1984. The average spread of submucosl carcinomas were 4.8cm2, which was two times wider than mucosal carcinoma. Fourteen patients were treated with Argon-Dye laser, three with Excimer-Dye laser and three with Yag-OPO laser. As total light dose of explosure were 40-150 J/cm2, wider submucosal carcinoma cases recieved less dose than smaller mucosal carcinoma cases. In evaluable 19 cases excluding 1 drop-out, three cases remained remnant lesion and two cases were relapsed locally. The cause of treatment failure was supposed to be from inadequate light dose and laser sourse. Although three remnant cases recieved re-PDT and achieved CR finally, one of the two relapsed patient was dead of metastatic cancer and another patient was performed surgical redection recently. Closing response rate as a local treatment was 89.5%. In summary PDT is considered to have a great potential for controlling the localized superficial carcinoma of the esophagus.
