Abstract
Laser irradiation with the wave length, variable generator (I.H.I.Co.) was given to aquaeous solutions of such inflamatory mediators as prostaglandin E1, histamine and bradykinin or healthy human serum and effects of the wave length or energy density ranging from 266 to 780 nm or from 20 to 200 mw/cm2 on their concentrations measured by fluolescence method or RIA were examined to get an insight into the possible mechanism for the RA laser therapy. When the laser with 266 nm of wave length was irradiated, an increase in the laser intensity or energy fluence caused a propotional decrease in the concentration of prostaglandin E1, serum LDH and ALP activity and Albumin/Globulin ratio. Ten times increase in the laser intensity or fluence produced an decrease in prostaglandin E1 to one fifth. When the laser with 180 mw/cm2 of intensity was irradiated, the laser with the less wave length than 532 nm caused a clear decrease in bradykinin concentration. The laser with 266 nm of wave length but not with the other wave length produced a marked decrease in prostaglandin E1, histamine, serum total protein, GOT, GPT, LDH and ALP.
