Abstract
There has been increasing interest in the usage of porphyrins for tumor localization and therapy. Hematoporphyrin derivative is well-known tumor-specific photosensitizer. Hematoporphyrin derivative has been used clinically as a photosensitizer in photodynamic therapy (PDT). PDT is performed after hematoporphyrin derivative i. v. injection. Therefore, hematoporphyrin derivative may interact with serum components. We investigated the binding affinity of hematoporphyrin derivative to albumin, on of the serum components. Most hematoporphyrin derivative binds to albumin among all the serum protein in vitro. Therefore, alubumin binding hematoporphyrin derivative decreased according to the time after injection. This decreasing present were 19.6%, but other serum components were not change. In stead of albumin binding hematoporphyrin derivative, tumor binding hematoporphyrin derivative were increased to time after injection. These result suggest that albumin may be hematoporphyrin derivative carrier protein.
