Abstract
Epidemiological analyses of cleft lip/plate have often been performed, and multiple factors, including genetic and environmental agents, have been reported to be the causative factors. In this study, we investigated the association of cleft lip/palate with maternal age at delivery, parental smoking, and maternal alcohol consumption. The study population was comprised of 1,273 cases who had visited the Plastic and Reconstructive Surgical Department of Showa University before surgical operation from January 1989 to December 2005. We compared the data with the past data in our department and the statistical data from the Ministry of Health, Labour and Welfare. We found that maternal age and parental smoking rate were significantly associated with the occurrence of this disease, whereas there was no significant association with alcohol consumption rate.
