Abstract
Several reports relative to the estimation of sulfamin drugs in saliva have hitherto published. However, they were all on the mixed saliva.
Following previous reports, (I) and (II), the author obtained the following results after estimation of sulfamin drugs in the mixed saliva and the secretion of sublingual gland, which was collected by means of a specific apparatus for collecting secretion of sublingual gland.
When each of various sulfamin drugs alone were administered orally, almost no discharge of the drugs in the secretion of the sublingual gland was observed in the case of sulfathiazol, but a fairly large amount of sulfadiazin was found to be discharged in the same secretion.
When the results were analysed with the natures of various sulfamin drugs in view, those sulfamin drugs reported to be easily transferable to various tissues were discharged from the sublingual gland, and those not were found not to be discharged into secretion of the sublingual gland or into the mixed saliva.
The sulfamin level in the secretion of sublingual gland was always lower compared with that in the mixed saliva.
In the case of intravenous injection, the maximal level was reached within 1-2 hours from the injection, and the level became undetectablly low within a short period of time.
When sulfamin drugs were consecutively administered in the case of laryngeal illness, a large amount of sulfamin drug was detected in the mixed saliva, although not a large amount of the drug was detected from the secretion of sublingual gland. This finding was irrespective of the natures of the drugs administered.
