Numerous papers related, to the amylase in saliva have hitherto published. However, all of them were investigations on the mixed saliva. The author collected samples of saliva separately from parotid gland, sublingual and submaxillary glands according to the procedures described in his previous paper, and estimated the amylase content according to Wohigemut's method.
The results indicated that the mean value in 20 Japanese cases was 1, 068 D 38° 30'. The amylase content demonstrated no marked change even in the case of a very active secretion of saliva.
Even violent mastication did not affect the amylase level in saliva.
Only in hunger, the amylase level was found raised.
Also in the samples from sublingual and submaxillary glands, starch splitting enzymes, though small in amount, were deteded.

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Several reports relative to the estimation of sulfamin drugs in saliva have hitherto published. However, they were all on the mixed saliva.
Following previous reports, (I) and (II), the author obtained the following results after estimation of sulfamin drugs in the mixed saliva and the secretion of sublingual gland, which was collected by means of a specific apparatus for collecting secretion of sublingual gland.
When each of various sulfamin drugs alone were administered orally, almost no discharge of the drugs in the secretion of the sublingual gland was observed in the case of sulfathiazol, but a fairly large amount of sulfadiazin was found to be discharged in the same secretion.
When the results were analysed with the natures of various sulfamin drugs in view, those sulfamin drugs reported to be easily transferable to various tissues were discharged from the sublingual gland, and those not were found not to be discharged into secretion of the sublingual gland or into the mixed saliva.
The sulfamin level in the secretion of sublingual gland was always lower compared with that in the mixed saliva.
In the case of intravenous injection, the maximal level was reached within 1-2 hours from the injection, and the level became undetectablly low within a short period of time.
When sulfamin drugs were consecutively administered in the case of laryngeal illness, a large amount of sulfamin drug was detected in the mixed saliva, although not a large amount of the drug was detected from the secretion of sublingual gland. This finding was irrespective of the natures of the drugs administered.

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Various measurements in the eye region and other various face measurements basing Baelz's so-called the false lateral angle of the eye were taken on 788 male and 827 female, totalling 1, 615 primary school children residing in Tokyo ranging from 7 to 12 years of age. Further, the morphological changes of the face by growth was observed by numerous indices calculated from the above measurements.
1) The tendency of increase in the mean values of the face measurements by growth was generally observed both in male and female children.
2) The difference between the mean values of various measurements based on the false lateral angle of the eye in the right and left sides was not distinct in both male and female children through all age groups and height groups.
3) The difference between the mean values of various measurements based on the false lateral angle of the eye in both sexes in certain age groups or height groups are clearly recognized. In certain groups, the values in male was greater than that of female, and in some groups there was no distinct difference between them. As a whole, the values in male suggested to be greater than that of female.
4) Certain indices demonstrated the tendency of increase by growth, but in some others, the tendency was on the reverse side. In some instances, the indices were found to be kept unchanged through all age groups. However, generally speaking, the difference in the mean value of the indices in the right and left sides and in both sexes were not recognized.
5) No fixed transition in the types by the progress of age was recognized in cover-fold, the direction of palpebral fissure, shape of palpebral fissure, width of palpebral fissure and shape of eye brow, but certain fixed correlationships were recognized between cover-fold and shape of palpebral fissure, cover-fold and the width of palpebral fissure, shape of palpe-bral fissure and the width or palpebral fissure, shape of eye brow and the width of palpebral fissure and the shape of eye brow and the shape of forehead respectively.

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In the present paper, the authors state their experiences in the treatment of 11 cases of surgical tuberculosis which were treated with isonicatinic acid hydrazid (INAH) for more than 5 weeks selected from 25 cases which were under the treatment with INAH.
The selected cases consisted of 8 cases of tuberculosis of cervical lymphnodes, 1 case of fistulated tuberculous pyothorax, 1 case of fistulated tuberculous peritonitis and 1 case of tuberculosis of digital bone.
Only 5 of the above cases had never been treated prior to INAH treatment, and the rest of them had been treated either streptomycin, PAS or X-Ray irradiation.
During the 1 st week of the treatment, the dosage per os was 2 mg/kg, the 2 nd week 3 mg/kg, and 4 mg/kg thereafter.
As the results up until today, 6 out of 8 cases of tuberculosis of cervical lymphnodes were either cured or improved. As to the 2 cases of tuberculous fistula, which had been treated with streptomycin without success, 1 was cured in the 5 th week and another demonstrated remarkable improvement (almost complete closure of the fistula) .
Relative to the case of tuberculosis of digital bone, remarkable improvements such as diminution of swelling and favorable X-Ray findings were observed.
During the treatment, almost no side effects were noticed. In the majority of the cases, favorable changes were noted in their general conditions. Of course we know the necessity of the longer period observation, but, we can say the very favourable effect of INAHH in the treatment of surgical tuberculosis at least in the observation of this period.

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Following Togami's studies, the author investigated the influences of the splenic cornponents of various animals, especially of cattle, on the experimental hepatic disturbances in mice induced by carbon tetrachloride. In view of Togami's report that tyrosine-like substance contained in the splenic components of cattle possesses a strong inhibitory action against hepatic disturbances, experiments with the combination of splenic components with tyrosine were also conducted. Experiments with leucine and methionine were also performed.
1) The hepatic disturbances intmice intoxicated by carbon tetrachloride was inhibited, though slightly in degree, by the alcohol soluble extract of dehematized spleen of cattle.
2) In the case of application of the combined (A), (B) and (C) solutions isolated from the alcohol insoluble fraction of the splenic components of cattle, fairly strong inhibitory action on the hepatic disturbances was recognized.
3) In the case of application of the combination of splenic components with 1-tyrosine, the inhibitory action became marked, and the splenic components promoted the inhibitory action of 1-tyrosine.
4) In the cases of 1-leucine and dl-leucine, no inhibitory action was recognized, and even with the combination with splenic components, no marked promoting action was recognized.
5) The inhibitory action of methionine, especially of 1-methionine was intense. In the case of application of combination with splenic components, the inhibitory action became further stronger.

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In his previous report, the author confirmed that the inhibitory action of 1-tyrosine on the hepatic disturbances in mice induced by carbon tetrachloride is promoted by the combination with the Splenic components, and further, similar results are obtained in the cases of methionine, especially of 1-methionine. Also in the present experiments, the author considers that probably the hepatic disturbances in chick embryo induced by carbon tetrachloride are reduced by the cooperative action of methionine combined with the splenic components.
The hepatic disturbances in chick embryo induced by carbon tetrachloride is markedly reduced by injection of methionine combined with the acetone insoluble extract of cattle spleen.

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Relative to the analgesic action of vanilline and salicylaldehyde reported by Prof. Tsunoo, there are numerous points to be investigated and traced, which are left untouched, in the phases of its mechanism of action. In the present paper, the author deals exclusively with the local anaesthetic action of aromatic aldehydes specifically of vanilline. As the control substance for vanilline, cocain was employed, and as aldehydes, salicylaldehyde in addition to vanilline were selected. As furan compounds, furfurol, oxymethylfurfurol, acetyioxymethylfurfurol, di- (furfurol-methy1-2) -ether, etc. were employed for the experiments. In author's Department, glycocoll and taurin were frequently used for the studies on vanillin in the past; therefore, histidin and isoserin was also included. As aminosulfonic acid of taurin series, L-amino-2-oxypropansulfonic acid, 1-pyridy1-2-oxypropansulfonic acid, benzoylaminooxypropan-fulfonic acid, and as a special case, taurocholic acid were included. Excepting taurin and isoserin, the above three derivatives of aminosulfonic acid possess OH-radical in their molecules; therefore, the author considered that they might affect the local anaesthetic action of vanilline. As the control substance for aldehydes, vanillic acid, oxymethylpromucinic acid and bis- (carboxyfuran) -methylether were added.
1) In the application of vanilline alone, the anaesthetic action in the rabbit cornea could not be recognized, but it faintly enhanced the same action of cocain.
2) In the applications of vanilline combined with taurin, glycocoll, taurocholic acid, aminooxypropansulfonic acid and its derivatives and histidin respectively, the anaesthetic action of vanilline in the cornea did not appear.
3) The anaesthetic action of vanilline in the surface of the leg of frog exceeds that of cocain.
4) In the combined application of vanilline with equal mol of cocain, the surface anaesthetic action was enhanced, but no enhancement was recognized in the combination with 2 mol of cocain.
5) In the combined application of vanilline with equal mol of procain, the surface anaesthetic action was reduced. Probably, this is due to the inactivation of CHO-radical, which is the active atomic group in the molecule of vanilline, as a result of chemical reaction between vanilline and cocain or procain.
6) In the combined application of vanilline with taurin or glvcocoll, the surface anaesthetic action was enhanced.
7) The surface anaesthetic action of furfurol, oxymethylfurfurol, and acetyloxymethylfurfurol was intense.
8) The paralytic action of vanilline to the motorial fibers of sciatic nerve of frog was much more intense compared with that of cocain. Furf urol and acetyloxymethylf urfurol also demonstrated an intense action.
9) The anaesthetic action of vanilline to the sensory fibers of sciatic nerve of frog was much more intense compared with that of cocain. The action of salicylaldehyde was even further more intense.
10) The combination with oxyamino acids or oxyaminosulfonic acids such as isoserin, aminooxypropansulfonic acid, benzoylaminooxypropansulfonic acid and pyridyloxypropansulfonic acid did not generally affect the local anaesthetic action of vanilline.

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The author conducted various experiments placing the emphasis on the detection of Br-vanillic acid, ethereal sulphate or glucuronids. Simultaneously, the toxicity of Br-vanilline was compared with that of vani (line, thus the significance of brominization was studied. From the pathological and histological findings of liver of rabbit administered with Br-vanilline in an attempt to estimate the grade of the toxicity of Br-vanilline.
1) From the urine of rabbits administered with Br-vanilline, crystals of a glucuronid-like substance of Br-vanillinic acid (C₁₄H₁₅O₁₀Br) possessing the melting point of 225°-230°C (with decomposition) were isolated.
2) The ethereal sulphate content of the urine of rabbit administered with Br-vanilline remarkably increased.
3) The ethereal sulphate content of the urine of rabbit administered with salicylaldehyde or salcylamine also clearly increased.
4) Br-vanilline is less toxic than vanilline in mice.
5) The pathological histoiogical findings in the liver of rabbit administered with Br-vanilline is relatively mild.

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Despite the tact that cases of Leucoderma senilis among patients visiting this outpatient department are being met, almost no literatures related to this illness are found. In view of the above, the author investigated, cases of this illness clinically and histologically, the outline of the findings of which are described in the present paper.
Leucoderma senilis occurs clinically in the persons under 30 years of age in some instances. The size ranges from millet grain to soy-bean size (generally rice grain size) . It appears as well defined pale or light yellow colored spot. In the majority of the cases, the shape is round. No desquamation or vasicle formation is recognized. It does not form scar, and accompanies no sensory abnormalities. As the age progresses, the frequency becomes larger. No tendency of increase in size is recognized. It appears more frequently on the trunk especially in the median region. The most resemblingg disease to this is white spot disease. Hawever, it lacks changes in E. f.
Histologically, the change in E, f. and K. f. is generally the characteristic senile changes. Leucoderma senilis appears in the region where the senile changes, which is a physiological phenomenon, is specifically marked.
In short, Leucoderma senilis is one of the physiological phenomena, and it seems that the disease appears where senile changes are specifically marked.

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