1953 Volume 13 Issue 1 Pages 32-48,67
The author investigated the influences of the splenic components combined with aldehydes on the experimental hepatic disturbances induced by carbon tetrachloride in mice.
In the first place, the influences of furan aldehyde on the reticuloendotherial system were investigated and the following brief conclusions were drawn.
I) Acetyloxymethylfurfural, oxymethylfurfural and furfural posess an evident activating activity to the reticuloendotherial system. The activity of Di- [furfural-methyl-2] -ether is less active, and the activity of Bis- [carboxy-furan] -methylether and oxymethyl pyromucic acid is even further less than the first three.
II) The inhibitory activity against the hepatic disturbances induced by carbon tetrachloride.
1) The combined administration of acethyloxymethylfurfural with benzol soluble extract or ether insoluble extract of bovine spleen clearly inhibits the hepatic disturbances.
2) The combined administration of oxymethylfurfural with acetone soluble extract or ether insoluble extract of bovine spleen clearly inhibits the hepatic disturbances.
3) The administration of vanillin combined with ether soluble extract or with insoluble extract clearly inhibits the hepatic disturbances.
4) The administration of salicylaldehyde combined with alcohol soluble extract or with ether insoluble extract evidently inhibits the hepatic disturbances.
5) Strongest inhibition was noted in the case of the administration of acetyloxy-methylfurfural combined with either of these extracts.
6) The inhibitory activity in the cases of the administration of acetyloxymethylfurfural or vanillin combined with the alcohol insoluble fraction of the bovine spleen are slightly weaker compared with that in the cases combined with various extracts isolated from the alcohol soluble fraction of the former.
7) For the mechanism of the inhibition of the hepatic disturbances, the activation of the reticuloendotherial system by aromatic aldehydes, furan aldehyde and by the splenic components is considered to be one of the principal factors.
