STUDIES ON ENEMA

Absorption of Aminoacids in the Colon

Abstract

As part of the studies on the enema which are being carried out in the Department of Pharmacology for many years, the author investigated the absorption of aminoacids from the colon, and further investigated the influences of various combined substances on the absorption of aminoacids from the colon. For the present study, the author selected glycocoll and taurin as aminoacids and investigated the changes of amino-nitrogen content and residual nitrogen content in the blood before and after these aminoacids were administered as enema alone or in combination with various other substances. In addition, the serum calcium content was also estimated in the case where calcium preparation was administered in combination with the aminoacids for the purpose to survey the relationships to the absorption of calcium which had already been clarified by Hitomoto, Kato et al. The results obtained are as follows:
The absorption of glycocoll in the colon is directly promoted by the combination with monosaccharids, disaccharids, calcium chloride and some of the narcotics. Bovine bile remarkably promotes the absorption of glycocoll or taurin in the colon when it is combined with calcium preparation (Ca-chloride, Ca-sulfate or Ca-lactate) and glucose or fructose simultaneously.