Sulfonamide剤の大腸内吸収に関する研究

抄録

The author systematically investigated the absorption of sulfonamide preparations in the large intestine, thereby he attempted to make a contribution to the elucidation of the mechanisms of the absorption of various substances in the large intestine.
Aiming at the survey of the absorption promoting substances, magnesium sulfate, urethane, chloral hydrate, cattle bile and urea were administered in combination. Urethane, chloral hydrate and cattle bile were employed for the experiments by the reason that these substances often acted promotingly in the absorption of penicillin, PAS and streptomycin in the large intestine. Magnesium sulfate was adopted as the control substance to the r above substances. Urea was also adopted because of the fact that urea is heretofore believed to act promotingly in the absorption of sulfonamide preparations when combined with sulfonamide preparations.
The following was the conclusions obtained :
The absorption of sulfonamide preparations in the large intestine is promoted by urea, chloral hydrate, cattle bile and urethane administered as combined substances. Furthermore, the absorption promoting action of these substances is stronger in the order as described in the above. On the other hand, magnesium sulfate, administered in combination does not act promotingly, but occasionally acts inhibitorily on the contrary.