Abstract
As a part of the series of studies on the absorption of histamine in the large intestine, which are being conducted in the authors' Department, the authors investigated the influences of sulfonamides, streptomycin and magnesium sulfate on the absorption of histamine in the large intestine in an attempt to discover methods for the alleviation of the manifestation of the symptoms induced by histamine. Further, it must be added that the present work has been conducted during the rainy season in Japan, in which dysentery or Ekiri tend to occur. The following conclusions were thus obtained.
The absorption of histamine in the large intestine is only very slightly promoted even when histamine hydrochloride, magnesium' sulfate and sulfonamide are administered in combination. Even further addition of streptomycin to the above combination promotes only slightly the absorption of histamine in all cases without the manifestation of intoxication symptoms induced by histamine. Furthermore, the absorption of sulfonamide and streptomycin in the large intestine is inhibited compared with the cases when either of them is administered alone, while the absorption of magnesium sulfate is generallyy promoted slightly.
