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Volume 14, Issue 4
Displaying 1-9 of 9 articles from this issue
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On the Influences of Magnesium Sulfate, Sulfonamides and Streptomycin on the Absorption of Histamine in the Large IntestineEisuke Matsumoto, Shunji Ota, Tomosaburo Kono, Tsunaharu Tsuchimochi, ...1954 Volume 14 Issue 4 Pages 269-275
Published: September 30, 1954
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAs a part of the series of studies on the absorption of histamine in the large intestine, which are being conducted in the authors' Department, the authors investigated the influences of sulfonamides, streptomycin and magnesium sulfate on the absorption of histamine in the large intestine in an attempt to discover methods for the alleviation of the manifestation of the symptoms induced by histamine. Further, it must be added that the present work has been conducted during the rainy season in Japan, in which dysentery or Ekiri tend to occur. The following conclusions were thus obtained.
The absorption of histamine in the large intestine is only very slightly promoted even when histamine hydrochloride, magnesium' sulfate and sulfonamide are administered in combination. Even further addition of streptomycin to the above combination promotes only slightly the absorption of histamine in all cases without the manifestation of intoxication symptoms induced by histamine. Furthermore, the absorption of sulfonamide and streptomycin in the large intestine is inhibited compared with the cases when either of them is administered alone, while the absorption of magnesium sulfate is generallyy promoted slightly.View full abstractDownload PDF (935K) -
Yoshio Fukuda, Masao Ishii, Noboru Kawanami1954 Volume 14 Issue 4 Pages 276-278
Published: September 30, 1954
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSCultural examinations for tubercle bacilli were conducted on the specimens of whole sputum from 10 tuberculous prtients, who have completed the active treatment and were introduced into the stage of the treatment by walking, but who are found discharging a trifle number of tubercle bacilli when examined by cultivation of sputum, and the whole course of discharging the organisms was observed.
As to the tendency of the discharge of the organisms, the following 3 types were recognized.
Type 1. After a negative stage for more than 1 month, discharge or a trifle number of organisms for a short period is observed.
Type 2. Discharge of organisms in trifle number is recognized at intervals of less than 1 month.
Type 3. Explosive increase and decrease in the number of organisms discharged are observed.
In the second stage of the present work, INAH was administered to these patients and the effect to the patients was observed. The rate of decreasd in the number of discharged organisms was observed more iminently in the cases which were discharging greater number of organisms prior to the administration of INAH, but the prolongation of the negative and the decrease in the number of colonies seen on the medium were recognized in all of the patients observed in the present work.View full abstractDownload PDF (371K) -
Miyoshi Masui, Isao Shinjo, Masatoshi Higano, Yoshihiro Nakamura1954 Volume 14 Issue 4 Pages 279-283
Published: September 30, 1954
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe thresholds of double-condenser discharge current were measured on the sciatic nerve of Bufe vulgaris. The stimulating current produced by two-condensers discharge is consisted of two portions, i.e. ascending and descending portions. When the ascending time of stimulating current is short, the threshold is high, and the prolongation of the ascending time causes to lower the threshold values, and when an adequate value is chosen as the ascending time, the threshold becomes minimal. And further prolongation of the ascending time over that adequate value, the thresholds are elevated again.
The wave form of the stimulating current which shows the minimal threshold value, does not coincide to that of action current. It was elucidated that the stimulating action was caused only by the ascending portion of the double condenser discharge current, and not by the descending porton.View full abstractDownload PDF (598K) -
Yasuteru Karaki1954 Volume 14 Issue 4 Pages 284-291
Published: September 30, 1954
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSFollowing the preceding research works, the author investigated, as part of the pharmacological studies on the embryonal stage, the influences of parotin on the adrenalin content in the adrenal gland of the chick embryo. Further, the investigation of the influences of the combined administration of parotin and nicotine, and the histological examinations of the adrenal gland were also conducted simultaneously. The following results were thus obtained.
1. The injections of 0.1γ and 0.01 mg of parotin did not exercise any influence on the adrenalin content of the adrenal gland of the chick embryo.
2. The adrenalin content of the adrenal gland of the chick embryo was increased to more than twice as much as the controls by the injections of 0.2 mg or 1.0 mg of parotin.
3. In the cases with combined administration of parotin and nicotine, the adrenalin content in the adrenal gland was found increased, but the degree of the increase seemed less than that in the cases with single administration of parotin.
4. As histological findings, in the case of the injection with more than 0.2mg of parotin, the promotion in the development of the medullary substance of adrenal gland was noted when compared with the controls.View full abstractDownload PDF (12757K) -
Sigetaro Kinosita, Masatosi Higano, Tihuyu Takesige, Shin Akamatsu1954 Volume 14 Issue 4 Pages 292-296
Published: September 30, 1954
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESS1. Action potentials were led from the uterine muscle by the needle electrodes or by the co-axial electrodes.
2. The wave forms of action potentials which are supposed to be led from several excitable units, are diphasic or triphasic.
3. The longest duration of spontaneous action potential is about 300 msec., andd that which evoked by stimulation is 300-400 msec.
4. The duration of action potential is affected by the distance of both electrodes. Stronger stimulation evokes stronger action potential and the duration of it also increases. And, when the stimulus reaches some definite strength, the duration and strength of the action potential show their maximal values, and notwithstanding further strengthening of the stimulus, it maintains these values. The conduction velocity of the impulse in the uterine muscle is 1.83 cm/sec at 26°C.
5. From the above mentioned results, the authors concluded that the “all or none” law is valid for the excitable unit of uterine muscle.View full abstractDownload PDF (9677K) -
Kenichi Irisawa, Akira Sakai, Shigetsugu Yamaguchi, Keigo Hasegawa1954 Volume 14 Issue 4 Pages 297-301
Published: September 30, 1954
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe authors investigated the influences of vitamin B1 (B1), thiamine-propyl-disulfide (TPD) and thiamine-allyl-disulfide (TAD) on the phagocyticfunction of the reticuloendothe-lial system of liver. The following conclusions were thus drawn.
1. In the cases of single administrations, B1 accelerates the phagocytic function of the stellate cells of the liver more strongly compared with TPD or TAD. The acceleration by TPD is slightly stronger or just comparable with that by TAD. Generally, the phagocytic function sppears more strongly in the cases with injections of higher concentration, in which higher death rate is experienced, than in the cases with injections of lower concentration, in which lower death rate is experienced.
2. In the cases with successive single administrations, TAD activates the reticuloendothelial system most strongly in general. B1 follows TAD. The influnece of TPD is found miler compared with the first two. When compared with the cases with 1 single injection, the phagocytic function is stronger.
3. In the cases with combined injections, the activation of phagocytic function by the combined administration of B1 and TPD is most remarkable and the combination of TPD and TAD follows the former. The influence by the conobination of B1 and TAD appears milder. The over-all observation indicates a tendency that stronger phagocytic function appears with higher concentration than with lower concentration.View full abstractDownload PDF (652K) -
Saburo Tsukioka1954 Volume 14 Issue 4 Pages 302-321
Published: September 30, 1954
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESS1) The body weight of the chick embryo is increased, though slightly, by the treatment with procaine penicillin-G, while bornylamine penicillin-G acts inhibitorily on the development. The action of bornylamine itself is also inhibitory to the development.
2) The amount of allantoic fluid is not particularly influenced by either procaine penicillin-G, bornylamine penicillin-G or by bornylamine hydrochloride.
3) In the cases treated with bornylamine penicillin-G or with bornylamine hydrochloride, malformations in the chick embryo are noted, while no such malformations are observable in the cases treated with procaine penicillin-G. In either of the above cases, perfect hatchings were successfully accomplished.
4) Even in the cases treated with 12 mg of procaine penicillin-G, the amount of penicillin excreted in the allantoic fluid is only minute. Similarly to the above, the amount of penicillin excreted in the allantoic fluid is also minute even in the cases treated with 12 mg of bornylamine penicillin-G.
5) The damage on the liver cells inflicted by procaine penicillin-G is relatively mild, while the damage inflicted by bornylamine penicillin-G is fairly severe. The damage on the liver cells inflicted by bornylamine hydrochloride is even more severe compared with those by bornylamine penicillin-G.
In short, among procaine penicillin-G, bornylamine penicillin-G and bornylamine hydrochloride, only procaine penicillin-G acts slightly promotingly on the development of chick embryo, while bornylamine penicillin-G and bornylamine hydrochloride act inhibitorily. The damage on the liver cells inflicted by procaine penicillin-G is also milder compared with those inflicted by the remaining two substances. Further experiments revealed that the damage inflicted on the liver cells and the development inhibitory action are originated from the bornylamine which is the constituent of bornylamine penicillin-G. Furthermore, the major part of the procaine penicillin-G or the bornylamine penicillin-G given to the chick embryo is considered to be splitted within the body of the chick embryo since the amounts of procaine penicillin-G and bornylamine penicillin-G excreted in the allantoic fluid are minute.View full abstractDownload PDF (12511K) -
Eizaburo Hosoi, Sin Akamatu, Masaru Sato, Hyoe Ogawa, Sigetaro Kinosit ...1954 Volume 14 Issue 4 Pages 322-326
Published: September 30, 1954
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe action potential was led from the retractor muscle of the laryncus of Euhadra and Eulota, and recorded by the cathode ray oscillogragh. The monophasic action potential showed a triangular shape. If the muscle is stretched, there occurs repetitious excitations, which are supposed to be neurogenic.View full abstractDownload PDF (9960K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1954 Volume 14 Issue 4 Pages 327-328
Published: September 30, 1954
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (298K)
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