ON THE INFLUENCES OF PAROTIN ON THE ADRENALIN CONTENT IN THE ADRENAL GLANDS OF THE CHICK EMBRYO

Abstract

Following the preceding research works, the author investigated, as part of the pharmacological studies on the embryonal stage, the influences of parotin on the adrenalin content in the adrenal gland of the chick embryo. Further, the investigation of the influences of the combined administration of parotin and nicotine, and the histological examinations of the adrenal gland were also conducted simultaneously. The following results were thus obtained.
1. The injections of 0.1γ and 0.01 mg of parotin did not exercise any influence on the adrenalin content of the adrenal gland of the chick embryo.
2. The adrenalin content of the adrenal gland of the chick embryo was increased to more than twice as much as the controls by the injections of 0.2 mg or 1.0 mg of parotin.
3. In the cases with combined administration of parotin and nicotine, the adrenalin content in the adrenal gland was found increased, but the degree of the increase seemed less than that in the cases with single administration of parotin.
4. As histological findings, in the case of the injection with more than 0.2mg of parotin, the promotion in the development of the medullary substance of adrenal gland was noted when compared with the controls.