Abstract
The authors investigated the influences of vitamin B1 (B1), thiamine-propyl-disulfide (TPD) and thiamine-allyl-disulfide (TAD) on the phagocyticfunction of the reticuloendothe-lial system of liver. The following conclusions were thus drawn.
1. In the cases of single administrations, B1 accelerates the phagocytic function of the stellate cells of the liver more strongly compared with TPD or TAD. The acceleration by TPD is slightly stronger or just comparable with that by TAD. Generally, the phagocytic function sppears more strongly in the cases with injections of higher concentration, in which higher death rate is experienced, than in the cases with injections of lower concentration, in which lower death rate is experienced.
2. In the cases with successive single administrations, TAD activates the reticuloendothelial system most strongly in general. B1 follows TAD. The influnece of TPD is found miler compared with the first two. When compared with the cases with 1 single injection, the phagocytic function is stronger.
3. In the cases with combined injections, the activation of phagocytic function by the combined administration of B1 and TPD is most remarkable and the combination of TPD and TAD follows the former. The influence by the conobination of B1 and TAD appears milder. The over-all observation indicates a tendency that stronger phagocytic function appears with higher concentration than with lower concentration.
