Abstract
As a part of the pharmacological studies on the embryonal stage, the author investigated the influence of streptomycin on the development of chick embryo and its excretion into the allantoic fluid, thereby attempted to contribute to the elucidation of the fate of streptomycin in the living body. Furthermore, in order to investigate the toxicity of streptomycin, pathological histological examinations on the liver and kidney were simultaneously conducted. The following conclusions were thus reached.
1) An adequate amount of streptomycin slightly promotes the development of chick embryo and tends to demonstrate a diuretic action. At the higher concentration, however, the development is found even inhibited, and an inhibition on diuresis is recognized.
2) In view of the fact that the amount of streptomycin excreted into the allantoic fluid is extremely scanty showing only 0.4-0.9 of the amount injected, the major part of the amount of streptomycin injected is considered to be decomposed in the developing egg.
3) Streptomycin elevates the pH value of the allantoic fluid.
4) According to the pathological histological findings, streptomycin is considered to cause a fair damage in the liver and kidney of the chick embryo at a high concentration.
