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Volume 15 (1955 - 195･･･
- Issue 6 Pages 369-
- Issue 5 Pages 333-
- Issue 4 Pages 247-
- Issue 3 Pages 181-
- Issue 2 Pages 99-
- Issue 1 Pages 1-
Volume 15, Issue 2
Displaying 1-9 of 9 articles from this issue
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Kiyoshi ANDO1955 Volume 15 Issue 2 Pages 99-103
Published: May 31, 1955
Released on J-STAGE: September 09, 2010
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Tadataka Nagami, Yoshiaki Inoue1955 Volume 15 Issue 2 Pages 104-107
Published: May 31, 1955
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSNumerous reports have been published related to the fact that, the excretion of pyrvric, lactic and α-keto-glutaric acid etc. in the urine is increased following the fructose injection to a man when compared with the results with glucose injection. Derived from the above facts, the difference between fructose and glucose in their metabolic pethways in the organismus was presumed. Therefore, the authors planned this experiment from the view point that a similar difference might exist concerning citric acid, which is the intermediates of the “Krebs's cycle ”. The following is the results obtained.
1) No definite tendency in the fluctuation of the amount of citric acid in, the urine was recognized when intravenous injections of fructose and glucose was given.
2) The excretion of calcium in the urine was found increased at 15 minutes after the injection of 50% glucose and 20% fructose when compared with the controls and with the result of 20 % glucose. However, no statistically significant change in urine citric acid was occured at any time after the both sugar injection, although a positive correlation was recognized between the amount of citric acid and the calcium in the urine.
3) A positive correlation between the pH of the urine and the amount of citric acid excreted in the urine was recognized.
4) The citric acid content in the urine and the citric acid concentration in the serum are not necessarily in parallel, but a positive correlation was recongized between them.View full abstractDownload PDF (596K) -
Masashi Takeuchi1955 Volume 15 Issue 2 Pages 108-129
Published: May 31, 1955
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAs a contribution to elucidate the influence of streptomycin on the animal in the embryonal stage, the author investigated the calcium metabolism of the chick embryo employing fertilized eggs, and then studied the influence of streptomycin on the development of embryo. Further, when the influence of streptomycin on the calcium metabolism was investigated, similar experiment with calcium chloride was simultaneously conducted. The author also investigated the changes observed when these two substances were administered in combination, and then the data thus obtained were statistically analysed in an attempt to presume the mechanisms of the influence of streptomycin on the calcium metabolism of the animal in the embryonal stage.
Summarizing the data obtained in the above experiments, it was concluded that, the calcium content in the embryo was found decreased when the embryo was treated with a large amount of streptomycin alone, but the calcium content was found increased when the embryo was treated with an adequate amount of streptomycin. When the embryo was treated with calcium chloride alone, the excretion of calcium was found promoted, consequently, a decrease in the calcium content of the embryo was recognized. The decrease in the calcium content of the embryo caused by the treatment with calcium chloride was found aleviated by the combination with streptomycin at 18 days after the hatching. In every case, the calcium content of the embryo was found fluctuating roughly in parallel with the weight of the embryo.View full abstractDownload PDF (3077K) -
Katsumi Ozawa1955 Volume 15 Issue 2 Pages 130-134
Published: May 31, 1955
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIt has already been made clear that, the rise in blood glucose after glucose infusion was higher than that of fructose following its administration. On the other hand, it has also been reported that the rise in lactate, pyruvate, a-ketoglutarate in the blood and the plasma citric acid following fructose administration is much higher and more rapid when compared with the case of glucose administration. In every case of these reports, however, infusions were given in a fairly large amount over a fairly long period of time, but not in a dose commonly administered for therapeutic purposes. Therefore, the author observed the fluctuation in the concentration of citric acid, calcium and inorganic phosphate in the blood serum after the injection of a dose routinely used for therapeutic purposes was given to healthy persons, thereby attempted to investigate the difference of these two sugars in their metabolic pathway. The following is the results thus obtained.
1. The rise in the serum citric acid following fructose injection was found higher than that of glucose injection and fall to the normal level 2 hours after the injection whereas following glucose injection the drop of serum citric acid below the normal level was ofsewed 2 hours after injection.
2. The drop in the level of inorganic phosphate in the blood serum was observed following either fructose or glucose injection, though the drop followed fructose injection was found smaller and more rapidly reached to the normal level. However, in the case of glucose injection, no tendency of recovering the level prior to the injection was noted even 2 hours after the injection.
3. The fluctuation in the concentration of calcium in the blood serum after fructose or glucose injection did not demonstrate any significant difference from that in the untreated cases.
From the above difference in the fluctuations of the citric acid and inorganic phosphate in the blood serum after the injection of these two sugars, and also from the fluctuations of the concentrations of blood pyruvate, lactate and a-ketoglutarate which were reported by earlier workers, the presence of a qualitative difference between fructose and glucose in their metabolic pathway was infered.View full abstractDownload PDF (627K) -
Susumu Togo1955 Volume 15 Issue 2 Pages 135-152
Published: May 31, 1955
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAs a part of the pharmacological studies on the embryonal stage, the author investigated the influence of streptomycin on the development of chick embryo and its excretion into the allantoic fluid, thereby attempted to contribute to the elucidation of the fate of streptomycin in the living body. Furthermore, in order to investigate the toxicity of streptomycin, pathological histological examinations on the liver and kidney were simultaneously conducted. The following conclusions were thus reached.
1) An adequate amount of streptomycin slightly promotes the development of chick embryo and tends to demonstrate a diuretic action. At the higher concentration, however, the development is found even inhibited, and an inhibition on diuresis is recognized.
2) In view of the fact that the amount of streptomycin excreted into the allantoic fluid is extremely scanty showing only 0.4-0.9 of the amount injected, the major part of the amount of streptomycin injected is considered to be decomposed in the developing egg.
3) Streptomycin elevates the pH value of the allantoic fluid.
4) According to the pathological histological findings, streptomycin is considered to cause a fair damage in the liver and kidney of the chick embryo at a high concentration.View full abstractDownload PDF (8317K) -
CHIU YEE YAN1955 Volume 15 Issue 2 Pages 153-154
Published: May 31, 1955
Released on J-STAGE: September 09, 2010
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Harunori Asakawa, Soko Makioka, Toyoo Kashiwakura1955 Volume 15 Issue 2 Pages 155-158
Published: May 31, 1955
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe authors have recently given transfusions of dried blood plasma to 16 cases and experienced jaundice in relatively many cases (5 cases) . It is generally believed that the jaundice due to dried blood plasma transfusion is mild and transitional. Therefore, only very few reports concerning this disease can be cited. In this respect, the authors considered it necessary to present their report concerning the cases of jaundice experienced by them. Moreorver, they recongnized the necessity even more strongly because the preparation of dried blood plasma they administered was claiming not to give rise jaundice as it had been irradiated by ultraviolet ray. The authors would be very happy if the present report would become a profitable reference for the workers in the same profession.View full abstractDownload PDF (408K) -
Takenori Hayashida1955 Volume 15 Issue 2 Pages 159-176
Published: May 31, 1955
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn an attempt to elucidate the influence of the substances of allithiamine group on the growth and development, the author, as the first step, planned to conduct a comparative examination of the influences of TPD and vitamin B1 on the general development of chick embryo. Simultaneously, the excretion of vitamin B1 into the allantoic fluid of the developing eggs treated with vitamin B1 or with TPD, and the total vitamin B1 content in the liver were examined, thereby the author attempted to get further clearer biological significance of TPD. The following is the results thus obtained.
No remarkable influence of vitamin B1 or TPD on the general development of chick embryo was recognized. However, when treated with a large dose, certain inhibition on the development was recognized, and a stronger inhibitive tendency was noted in the case of TPD.
The excretion of vitamin B1 into the allantoic fluid and the total vitamin B1 content in the liver were found increased by the treatment with vitamin B1 or with TPD. Especially, the excretion of vitamin B1 was found more strongly increased generally in the case of TPD. On the other hand, the total vitamin B1 content in the liver showed a tendency to be larger in the case of vitamin B1 compared with the case of TPD.View full abstractDownload PDF (8629K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1955 Volume 15 Issue 2 Pages 177-179
Published: May 31, 1955
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (402K)
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