Abstract
In an attempt to elucidate the influence of the substances of allithiamine group on the growth and development, the author, as the first step, planned to conduct a comparative examination of the influences of TPD and vitamin B1 on the general development of chick embryo. Simultaneously, the excretion of vitamin B1 into the allantoic fluid of the developing eggs treated with vitamin B1 or with TPD, and the total vitamin B1 content in the liver were examined, thereby the author attempted to get further clearer biological significance of TPD. The following is the results thus obtained.
No remarkable influence of vitamin B1 or TPD on the general development of chick embryo was recognized. However, when treated with a large dose, certain inhibition on the development was recognized, and a stronger inhibitive tendency was noted in the case of TPD.
The excretion of vitamin B1 into the allantoic fluid and the total vitamin B1 content in the liver were found increased by the treatment with vitamin B1 or with TPD. Especially, the excretion of vitamin B1 was found more strongly increased generally in the case of TPD. On the other hand, the total vitamin B1 content in the liver showed a tendency to be larger in the case of vitamin B1 compared with the case of TPD.
