Journal of The Showa Medical Association
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
THE EXPERIMENTAL STUDY OF PROTECTION AND RESTORATION BY ADMINISTRATION OF CO-ENZYME FACTORS AGAINST RADIATION DAMAGES
Yoshio AndoToshiro KamijoYoichiro MurayamaNoboru YamamotoSyoji Yoshizawa
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JOURNAL FREE ACCESS

1955 Volume 15 Issue 3 Pages 238-243

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Abstract
Authers studied protective and restorative effects of co-enzyme factors against lethal effects of X-ray on yeast cells, and some results were obtained.
1) Thiamine, pyridoxine and biotine showed no protective effect, and especially thiamine had almost no restorative effect.
2) Pantothenic acid (Na salt), nicotinamide, riboflavin, V.B12, CoC _??_ and A.T.P, s-howed protective effects some 15-35%. and also showed restorative effects in same degrees or more.
3) Cystenamine was one of the most effective competitive protector and restorator. (survivors=90%)
4) By administration of A.T.P. combined with cysteine or cystine, we obtained no protective effects but more restorative effects than the case when we applied each of them independently.
5) By combination of A.T.P. with pantothenic acid and nicotinamide, we obtained 70% survivors which were more effective than single administration of them.
6) About the concentration or comparative dose of co-enzyme factors when we apply them together we must study further to find out optimal comparative concentrations.
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