Abstract
As a part of the pharmacological studies on the embryonal stage, the authors investigated the changes in the chick embryo induced by the administration of Philopon employing fertilized hen's eggs to examine histologically the liver of the chick embryo. The results thus obtained were compared with those acquired in the past and came to the following conclusions.
1) As macroscopical findings, no eminent difference was noted in the initial stage of the incubation period when comared with the control. However, in the terminal stage, several grayish small specks were recognized in the parenchyma of the marginal portion of the liver in the cases when a highly concentrated philopon was injected.
2) As histological findings, since the initial stage of the incubation period, regressive degenerations such as granular degeneration, vacuolar degeneration, fat degeneration and necrotic or necrosis-like degeneration in the hepatic cells were recognized. In the terminal stage, round cells infiltrations in the Glisson's capsules were recognized.
3) The regressive degenerations observed in the liver of the chick embryo in the cases where a highly concentrated Philopon was injected indicated roughly the same tendency as that of the growth impediment in the terminal stage of the incubation.
