Abstract
Similarly to Nitromin, the administration of 250 u. of carzinophilin, an anti-tumor preparation, is capable of giving rise to a transient change in the testicular tissue of mouse.
The principal change is the inhibit ion of the cell division in each stage. Those influenced most are spermatogonia and spermatocytes f oxllowed by prespermatids and spermatids. Sertoli's cells and interstitial cells are least sensitive. The influence was most strongly observed 3-5 days after the administration, and on the 10 th day from the administration, recovery of the functions could be presumed. Furthermore, the mechanism of this action connot be explained in a single sentence. Although nutritional damages may be the one, the change is presumed to be due to a combination of various factors including the nutritional damage by carzinophilin.
