抄録
Presuming that follicular cells, oosperm or germinated ovum, which are young and active in cell division, may be liable to be affected by the antitumor substances, consequently, those substances may affect the functions of female reproductive organ, duration of pregnancy and the development of fetus, the authors experimentally observed the influences of carzinophilin, which has recently been developed as an antitumor antibiotic substance, on the f emal reproductive organ, particularly on the sexual cycle, ovulation and on. the pregnancy of various animals.
The sexual cycle of rats was modified by one administration of 83.9 u/100 g or more r and the cycle of the sexual excitement was found prolonged or lacking by the same dosis. As to the ovulation in rabbits, the ovulation test was positive with 10 ku. of Synahorin at 11 days after the termination of the administration of carzinophilin amounting even to 2, 500-15, 000 u. in total, showing the inability of inhibiting the ovulation. As regards the duration of pregnancy in mice, it was found that the duration was affected by the administration of 100 u. or more of carzinophilin in the initial stage and with 150 u. or more inn the middle stage causing discontinuation of the pregnancy. This effect became larger as the size of the dosis increased. However, in the terminal stage, almost no effect was observed. In the cases of the discontinuation of pregnancy, portions corresponding to the fetus were not recognized though the placenta was seen. Histological examinations revealed tha necrosis of placenta and hemorrhage in uterus. Furthermore, the fetal tissue was considered to be far more readily affected by carzinophilin than the tissue of placenta. Among the cases of continued pregnancy, still births were recognized. Nevertheless, no malformations were noted. When the drug was given the male and female before their copulation, the time lag between the copulation and the delivery was prolonged. The longestt was. 75 days. When only male animal was given, the period was found a little prolonged, showing an average of 34 days. The rate of survival of the youngs of the animals was found lower when both of the male and female were treated with the drug.
Thus, the authors learned that carzinophilin possesses similar effects against the functions of reproductive organ, duration of pregnancy etc. to those possessed dy such other antitumor substances as Nitromin, Azan, Sarkomycin etc.
