Abstract
1. One, 5, 10, 15, 20. 25, 30, 40, and 50 mg/kg of histamine were injected into young mice continuously for a period of 30 days. Then they were divided into two groups, such as those expiring at an early period (acute group) and those sacrificed after 30 days (chronic group) . A histopathological study was carried out with special reference to the changes of the lingual gland (Ebner gland) .
2. More remarkable changes in Ebner gland were observed in the former group. The changes become more conspicuous with increase of histamine in both groups, although this tendency was slight in the reticulum fibers of the basal membrane.
3. In the chronic group the changes caused by a large dose of histamine (Vacuolar degeneration, liquefaction and destruction of glandular epithelial cells, vacuolar degeneration and destruction of epithelial cells of the secretory duct, congestion of interstitial tissue) appeared together with the case of the acute group. (irregular arrangement, dissociation, cloudy swelling of glandular epithelial cells, desquamation and cloudy swelling of epithelial cells of the secretory duct, lymphocytic infiltration in interstitial tissue) .
4. The changes of the aeticulum fibers of the basal membrane were almost parallel with the pathological changes of the glandular epithelial cells in both group. The correlation to the degenerative changes of the glandular epithelial cells is stressed.
5. The various degenerative changes of the lingual glands in the present experiment were caused by the secondary direct and toxic action of histamine upon the Ebner gland.
