Abstract
I here are numerous studies published on the vitamin ditamin deficiency at the time of sulfa drug administration. Emphasizing the importance of metabolic factors as causes for this vitamin deficiency. investigations were made on human beings as well as by in vitro experiments.
When Sulfathiazale was administered per os on human beings, the ratio of the amount of ester type B1 against the total content of B1 in the blood showed a tendency to decrease. This tendency, however, was not so much remarkable when Sulfadiazine or Irgafen was used.
Moreover, the excretion of free B1 into urine after the loading of VB1 showed an increase when Sulf athiazole was administered.
Influence of sulfa drugs on the in vitro phosphalization of B1 was investigated by the use of the liver homogenate of mice. Into the reaction fluid, 3γ of VB1 was added, and after an incubation period of 40 minutes at 38°C, approximately 30% of tuh VB1 was found to be phosphalized. Wheras, when 1 mg/6 cc of Sulf athiazole was added into the reaction fluid, there was, virtually no phosphalization.
In view of the findings stated above, the inhibition of B1 phosphalization is considered as one of the cases for the development of B1 deficiency at the time of sulfa drug administration and this inhibition was most remarkable when Sulfathiazole was used.
