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Volume 19, Issue 10
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Muneyasu Kojima1959 Volume 19 Issue 10 Pages 925-942
Published: December 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSOn investigating the aerobic and anerobic glycolysis by Warburg's method, the author could clarify a part of the functions of human placental chorion.
1. The glycolytic activity of normal human chorion or placent is high in the early stage of pregnancy and it decreases following the advance in pregnancy. Those exceeded the day of anticipated delivery show still lower glycolytic activity.
2. The placenta of atonic labor generally shows a glycolytic activity higher than the placenta of natural delivery at the corresponding period.
3. The chorion or the placenta of miscarriage generally shows a value lower than that of the chorion or the placenta of normal parturition of the corresponding period, and the rate of decrease is greater in the earlier stage of pregnancy. This difference, however, becomes smaller from the middle stage of pregnancy. Cases with severer symptoms of miscarriage show stronger decrease in the glycolytic activity.
4. The glycolytic activity of the still-birth placenta is extremely low.
5. The glycolytic activity of the placenta of pregnancy toxemia is lower than that of the normal placenta at the corresponding period.
6. The glycolytic activity of normal pregnancy chorion is little influenced by estrogen of lower concentrations, but it is inhibited when the concentration is high.
7. The glycolytic activity of miscarriage chorion is not activated by estrogen and, instead, it is disturbed when the concentration is high. Progesterone too, though it enhances the lowered glycolytic activity at lower concentrations, it also inhibits at higher concentrations.View full abstractDownload PDF (2310K) -
Shigetaro Kinoshita, Toichi Irie, Chuan Shik Yu, Ichiro Osawa, Shusaku ...1959 Volume 19 Issue 10 Pages 943-951
Published: December 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe effect of tetrodotoxin (puffer poison) on the periferal nerve was studied using the sciatic nerve and gastrocunemial muscle preparation of Bufo vulgalis japonicus.
The nerve-muscle preparation was set in the separated-chamber, and tetrodotexin was administrated on it's nerve trunk. Square pulses were given on the nerve and strength-duration relation was investigated.
The standard solution which contains tetrodotoxin with dose of 50/14×420 times of the lethal dose of guinea pig, was diluted to 10-3 and 10-5 with Ringer's solution. Both 10-3 and 10-5 tetrodotoxin solutions elevated the strength-duration curve, and Weiss's formulas were valid for each case.
Weiss's formula and chronaxie calculated from Weiss's constants are as follows:
10-3 tetrodotoxin solution Weiss's formula chronaxie
before administration V=0.234/t+0.182 1.278 msec.
10 min. after V=0.187/t+0.390 0.505 msec.
95 min. after V=0313/t+1.67 0.187 cosec.
185 min. after V=0.909/t+1.571 0.579 cosec.
10-5 tetrodotoxin solution
before administration V=0.389/t+0.220 1.768 msec.
10 min. after V=0.305/t+0.335 0.910 msec.
2 hrs. after V=0.338/t+0.422 0.800 msec.
23.5 hrs. after V=0.350/t+0.81 0432 msec.
wash out with Ringer's solution and
21.5 hrs. after 10-6 Ach. V=0.280/t+0.19 1.473 msec.
Increased ratio of threshold voltage at different time-course following the administration of tetrodotoxin were compared with each other, in regard to different utilization-times, i.e. 0.14 msec., 0.42 msec., 0.98 msec., 2.1 msec, and 4.9 msec.
When low concentration of tetrodotoxin acted on the nerve for short time, the increased-ratios of threshold voltage became greater as the utilization-time shorter. But by long-time acting of low concentration tetrodotixin or the acting of high concentration tetrodotoxin, the increased ratios, vice versa, became greater as utilization-time longer.
Ach (10-6M) caused descendence of the strength-duration curve following the elevation by the effect of tetrodotoxin.
Chronaxies calculated from Weiss's constants became smaller with the decrease of the irritability by tetrodotoxin. But Ach lengthened the chronaxie shortened by tetrodotoxin.View full abstractDownload PDF (1004K) -
Masao Ohara1959 Volume 19 Issue 10 Pages 952-960
Published: December 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSI here are numerous studies published on the vitamin ditamin deficiency at the time of sulfa drug administration. Emphasizing the importance of metabolic factors as causes for this vitamin deficiency. investigations were made on human beings as well as by in vitro experiments.
When Sulfathiazale was administered per os on human beings, the ratio of the amount of ester type B1 against the total content of B1 in the blood showed a tendency to decrease. This tendency, however, was not so much remarkable when Sulfadiazine or Irgafen was used.
Moreover, the excretion of free B1 into urine after the loading of VB1 showed an increase when Sulf athiazole was administered.
Influence of sulfa drugs on the in vitro phosphalization of B1 was investigated by the use of the liver homogenate of mice. Into the reaction fluid, 3γ of VB1 was added, and after an incubation period of 40 minutes at 38°C, approximately 30% of tuh VB1 was found to be phosphalized. Wheras, when 1 mg/6 cc of Sulf athiazole was added into the reaction fluid, there was, virtually no phosphalization.
In view of the findings stated above, the inhibition of B1 phosphalization is considered as one of the cases for the development of B1 deficiency at the time of sulfa drug administration and this inhibition was most remarkable when Sulfathiazole was used.View full abstractDownload PDF (1142K) -
Eiichi Matsuda1959 Volume 19 Issue 10 Pages 961-985
Published: December 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAnti-tumorous substances are known not only to inhibit the proliferation of malignant cells but also to show varying inhibitory influences on the reproductive functions. Based on the studies hitherto published in this connection, experimental observations were made on the general growth, development of the bone and the sexual cycle of the litters born from the mother mice loaded with Carzinophilin, Nitromin or Tespamin in a dose not to cause abortion at varying stages of pregnancy. Stated in the following are the results obtained thereof;
1. Carzinophilin, Nitromin and Tespamin administered on the mice at varying stages of pregnancy were found to be inhibitory on the general growth of the litters born.
2. Development of the bone too is inhibited being expressed histologically in a form of incomplete osteoplasty.
3. Sexual cycle, especially, the first appearance of the estrus is delayed and the estrus itself is considerably inhibited.
4. Inhibitory influences listed above are stronger the larger the dose administered and the tearlies the stage of pregnancy. When the dose was limited to be smaller than the one to cause eabortion, the inhibitory influence on the general growth and the development of the bone of Carzinophilin was the strongest being followed by Tespamin and Nitromin in the order listed. But, the inhibitory influence on the sexual cycle was equivalent between Carzinophilin and Nitromin and Tespamin was the weakest among them.View full abstractDownload PDF (11381K) -
Sekiji Miyajima1959 Volume 19 Issue 10 Pages 986-1004
Published: December 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSExtracts prepared from the pleural exsudates or ascites of cancer patients by Nakahara's original method were found to depress the in vivo liver catalase activity of normal mice to an extent comparable to that of the cancerous tissue. Whereas, in vitro, the latter shows no depression on the catalase activity of liver homogenate, and the former shows remarkable depression.
On investigating similar extracts prepared from the normal tissue and noncancerous pleural exsudates and ascites as well, it was concluded that the reason why the tumor extracts show no in vitro depression is because the foreign materials contained there in activate the liver catalase activity.
Moreover, on investigating the in vitro influence of these 4 kinds of extracts on blood and crystalline catalase activity, it was concluded that the lowering of liver catalase activity in cancerous animals is not because of the direct destruction of catalase by the toxohormone of Nakahara et al, but because the changes produced in its environment or medium cause the regression of catalase activity. Namely, the point of attack of toxohormone is considered to be related to the pathophysiology of the entire organism rather than to the chemical construction of catalase itself.View full abstractDownload PDF (6042K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1959 Volume 19 Issue 10 Pages 1005-1007
Published: December 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (333K)
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