Abstract
In the presentexperiment, parathion was injected subcutaneously into rabbits twice weekly an intention of inducing fibrosclerotic changes of the kidney. The animal were divided into 4 groups of those receiving a dose of 2 mg, 4 mg, 8 mg and 12 mg/kg of parathion respectively. Histopathological changes of the kidney in the acute and chronic stages were studied.
1. Swelling, hyperemia, swelling and degeneration of the endothelia, increase in the number of nuclei, accumulation of fluid in Bowman's capsular space, hemorrhage and swelling of capsular epithelia were mild in those receiving 2 mg/kg and living for 120 days and 200 days. The changes were intensified following the increase in the dose of parathion to 4 mg/kg and 8 mg/kg and became most remarkable in those living for 120 days. The changes were somewhat milder in the group receiving 12 mg/kg, but those surviving for .200 days again showed still more remarkable changes.
2. In the group which died during the experiment, afore mentioned changes were: relatively mild in those given 2 mg/kg and milder in the group administered of 4 mg/kg. While, the changes became conspicuous in those given 8 mg/kg and 12 mg/kg. The changes were milder, however, when compared with the respective findings of the groups surviving for 120 days and 200 days.
3. Degenerative changs and desquamation of tubular epithelia, appearance of protein substance and red blood cells in tubules, homogenization and lytic changes of the tubular epithelia were mild in those receiving 2 mg/kg and surviving for 120 days and 200 days. The changes became remarkable with the increase of dosage and became most conspicuous in those administered of 8 mg/kg, while they became somewhat less conspicuous in those receiviving 12 mg/kg.
