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Volume 19, Issue 3
Displaying 1-12 of 12 articles from this issue
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Kanji Sawa1959 Volume 19 Issue 3 Pages 217-228
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn the present experiment, histamine hydrochloride was injected into young mice for a period of 30 days each in a daily dose of 1, 5, 10, 15, 20, 25, 30, 40 or 50 mglkg. The mice were divided into two groups of those died within a short period after starting injection and those sacrificed after 30 days of injection. Histopathological observation was made on the changes produced in the brain and the liver comparisons being made between the two groups and also by the difference of the dose of histamine administered.
1. In the acute group, congestion, dilatation of Virchow-Robin space, edematous rarefaction, degenerative changes of nerve cells and demyelinization were recognized. These changes became prominent with the increase in the dose of histamine.
2. In the chronic group, congestion and dilatation of Virchow-Robin space were always observed. Degenerative changes of the nerve cells appeared in the E group (20 mg) and edematous rarefaction was also recognized sporadically.
3. Central congestion, congestion of interstitial vessels, infiltration of lymphocytes, cloudy swelling, vacuolation fatty metamorphosis of liver cells were observed in both groups.
4. Since the pathologic changes of the brain and the liver first appeared in the blood vessels, in the present experiment, circulatory disturbance may be considered as the primary change of the toxic action from a morphological stand point.
5. The degenerative changes of nerve cells and liver cells were considered to have been induced indirectly by the influence of hypoxydosis caused by histamine and by the indirect action of histamine upon the cells.View full abstractDownload PDF (4389K) -
Rokuro Takayama1959 Volume 19 Issue 3 Pages 229-239
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn the presentexperiment, parathion was injected subcutaneously into rabbits twice weekly an intention of inducing fibrosclerotic changes of the kidney. The animal were divided into 4 groups of those receiving a dose of 2 mg, 4 mg, 8 mg and 12 mg/kg of parathion respectively. Histopathological changes of the kidney in the acute and chronic stages were studied.
1. Swelling, hyperemia, swelling and degeneration of the endothelia, increase in the number of nuclei, accumulation of fluid in Bowman's capsular space, hemorrhage and swelling of capsular epithelia were mild in those receiving 2 mg/kg and living for 120 days and 200 days. The changes were intensified following the increase in the dose of parathion to 4 mg/kg and 8 mg/kg and became most remarkable in those living for 120 days. The changes were somewhat milder in the group receiving 12 mg/kg, but those surviving for .200 days again showed still more remarkable changes.
2. In the group which died during the experiment, afore mentioned changes were: relatively mild in those given 2 mg/kg and milder in the group administered of 4 mg/kg. While, the changes became conspicuous in those given 8 mg/kg and 12 mg/kg. The changes were milder, however, when compared with the respective findings of the groups surviving for 120 days and 200 days.
3. Degenerative changs and desquamation of tubular epithelia, appearance of protein substance and red blood cells in tubules, homogenization and lytic changes of the tubular epithelia were mild in those receiving 2 mg/kg and surviving for 120 days and 200 days. The changes became remarkable with the increase of dosage and became most conspicuous in those administered of 8 mg/kg, while they became somewhat less conspicuous in those receiviving 12 mg/kg.View full abstractDownload PDF (5918K) -
Kazuo Mori, Kenichi Sugiura, Tsuko Nakagome, Kenichi Okamoto, Saburo S ...1959 Volume 19 Issue 3 Pages 240-244
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
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Kazuo Mori, Kenichi Okamoto, Kenichi Sugiura, Katsuhiko Matsumoto, Tsu ...1959 Volume 19 Issue 3 Pages 245-248
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
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Satoshi Hatate1959 Volume 19 Issue 3 Pages 249-252
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSCraniometric observations of various sorts of triangles formed by hypophyseal point as its base are of interest for both the scholars of anthropology and comparative anatomy. Stated in the following are the findings of the craniometric studies made on such triangles comparisons being made among different species of animals with special reference to the dog.
Mean of ∠APB in ΔAPB of the dog is 156.64°, and ∠PAB and ∠PBA of the dog are the smallest among all animal species examined.
In ΔPNA, ∠PNA of the dog is very large, while that of the human being is the smallest. ∠PAN and ∠PAN of the dog are the smallest, and these angles become larger in higher animals.
In ANB, ∠ANB of the dog is the largest, while that of the human being is the smallest. ∠NAB and ∠ABN of the dog are the smallest, and they become larger in higher animals.
In NPB of the dog, both ∠PNB and ∠PBN show minus, and ∠NPB is the largest with the mean of 197.85°. While, higher animal shows smaller ∠NPB.
As for the lengths of the sides forming above mentioned three triangles in the dog, the side AP is longer, the side PB is slightly shorter and the side AP is much longer than the respective findings of the human being.View full abstractDownload PDF (434K) -
Satoshi Hatate1959 Volume 19 Issue 3 Pages 253-255
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSInvestigations of the growth of skull, especially its evolutional processes measured from the hypophyseal point, are of much interest for both the scholars of ethnology and comparative anatomy. Above all, the comparative anatomy of the cranial curvatures of different species of animal is important from the standpoint of phylogeny, while practically no study of this type has appeared in the literature as yet.
Stated in the following are the findings of the investigation made on dogs comparisons being made with similar findings of other species of animal available.
The mean distance between P and Br is 3.86 ± 0.077cm,
P and H is 3.78 ± 0.089 cm, and
P and G' is 3.65 ± 0.085 cm.
No particular difference in the above measurements was observed by the difference of sex.
From the viewpoint of comparative anatomy, human beings show the longest distance in either one of the above three measurements, and those of the chimpanzee, gorilla, and Orang-Utah followed in the order listed. While, the dog show P-Br and P-H distances shor-ter than those of the anthropoid ape. On the other hand, the distance of P-G in the dog is shorter than that of the chimpanzee, but longer than that of the Orang-Utan or of the gorilla.View full abstractDownload PDF (301K) -
Junichi Toyama, Muneyasu Kojima, Hideaki Yamaguchi, Sadao Matsushima1959 Volume 19 Issue 3 Pages 256-259
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAs one of the unbloody therapeutic measures, anti-tumor substances have begun to be employed extensively for the treatment of malignant tumor especially malignant chorioepithelioma. On the other hand, those anti-tumor substances are known to influence on various functions of female genital organs. In this connection, the influence of anti-tumor substances on the oxygen consumption of human chorionic tissue was investigated in vitro.
Chorionic tissues employed in the present experiment were those collected from the women on the 8 th week to the 15 th week of normal pregnancy. The oxygen consumption of the chorionic tissue was determined by the use of Warburg's manometer. Anti-tumor substanes tested were Methyl bis (β-chloroethyl) amine N-oxide hydrochloride (N.M.O.), 8-Azaguanine (Az.), Sarkomycin (S. M.) and Carzinophilin (Cp.) .
The results obtained were as follows:
1. All the anti-tumor substances tested were found to reduce the oxygen consumption of human chorionic tissue remarkably when used in a high concentration.
2. Marked decrease in the oxygen consumption of human chorionic tissue was not noted when N.M.O., S.M. and Cp. were used in a low concentration.
3. While, the lowering of oxygen consumption by S. M. was relatively strong even at a low concentration.View full abstractDownload PDF (512K) -
Report 1. On the phagocytic action of neutrophilesYanosuke Matsumoto1959 Volume 19 Issue 3 Pages 260-263
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn vitro phagocytic action of neutrophiles was compared between the aged and they young and following results were obtained.
1. Generally, the phagocytic action of neutrophiles in the aged was inferior to thatt of the young.
2. The phagocytic action of neutrophiles in the aged was especially low on a short: period cultivation and its gradually increased with the elapse of time, but it was always lower than that of the young.
From the above mentioned observations, it is considered that the fall in phagocytic action of neutrophiles plays an important role in the fall of the resistance of the aged against diseases.View full abstractDownload PDF (417K) -
Report 2. Effect of various dynamic works on the phagocytic action of neutrophilesYanosuke Matsumoto1959 Volume 19 Issue 3 Pages 264-267
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSVarious dynamic works (R, M, R, 1, 2, 3, 4 and 5) were loaded on the aged and the young for 4 hours in order to make hourly observations of the hematologic changes produced. Following results were obtained:
1. The phagocytic action of neutrophiles was usually enhanced with the increase in the intensity of the load in the young, while, it usually decreased in the aged.
2. Generally, the number of leucocytes increased with the increase in the intensity of the load in the youg, while, it showed no significant increase in the aged till the steady astate was broken.
3. In the young, specific gravity of the blood increased in proportion to the intensity of the load, while, it increased in the aged even by the light load and was not proportional to the intensity of the load.
4. In the young, both the hemoglobin content and hematcrit value decreased during Lhe work, on the contrary, they showed an increase in the aged.View full abstractDownload PDF (538K) -
Report 3. Effect of various static works on the phagocytic action of neutrophilesYanosuke Matsumoto1959 Volume 19 Issue 3 Pages 268-272
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSVarious static works to carry a baggage (weighing 0, 5, 10, 15 and 20 kg) on the back were continued for 4 hours in the aged and the young. Hematologic changes, especially, the phagocytic action of neutrophiles were observed hourly.
With an intention of knowing the mechanism of such changes, observations were also made on the phagocytic action of the neutrophiles of the rat administered of adrenaline and pilocarpin by injection. The results were as follows:
1. In the young, the phagocytic action of neutrophiles showed a slight increase at the light load, but it showed a clear decrease at the heavy load. Findings of the aged were essentially the same as above.
2. The changes observed in the number of leucocytes were also the same as above.
3. Specific gravity of the blood, hemoglobin content and hematcrit value in the aged distinctly showed higher values than in the youg.
4. In the rat, the phagocytic action of neutrophiles was enhanced by the administration of adrenaline, whereas, it was reduced by the injection of pilocarpin.
From above mentioned observations, it is considered that the decrease in the phagocytic action of neutrophiles by loading the static work was probably due to paratonia. No difference was shown, however, between the aged and the young in this respect. But, as the hemoconcentration was higher in the aged than in the young, the former must have shown much stronger response than the latter.View full abstractDownload PDF (699K) -
Yoshimi Hagiwara, Masanori Matsumoto, Hidenobu Wakamatsu, Takeshi Taki ...1959 Volume 19 Issue 3 Pages 273-280
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSHistochemical technique for the localization of cholinesterase by Koelle has been modified and improved.
For the specific ChE determination 20% and for the non-specific ChE 24% Na2SO4 were used as storage solutions. Except Mal (NaH maleate: 1.9g, N·NaOH: 10.4ml., q.s 100ml., pH12.6), the same reagents for the incubation solution were used as Koelle's. Optimal pH of the incubation solution for the determination of specific ChE was 6.5-6.7 and for the non-specific ChE was 7.7-7.8. MgCl2 in the incubation media for the non-specific ChE determination was excluded since magnesium ions inhibited non-specific ChE competitively while they activated specific ChE.View full abstractDownload PDF (4989K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1959 Volume 19 Issue 3 Pages 279-280
Published: May 30, 1959
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (344K)
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