Abstract
Following the use of Evipan-Na by Weese in 1932, studies on the drugs for short period phlebonarcosis have become quite active and a number of preparations have appeared for this purpose, Thiamylal Sodium (Isozol) is one of the drugs thus appeared. Stated in the following are the findings of the use of this drug on a total of 110 cases of artificial abortion, endometritis and curettement.
1. The naccotic effect of Isozol was excellent through out all the cases administered. The appearance of narcotic effect was smooth by the administration of 0.21g in average and the period of narcosis was short being only 10.1 minutes in average.
2. No serious side effects were recognized, but there was a general tendency of lowering the blood pressure, this however was mild.
As for the pulse, there were a few cases of arythmic and intermittent pulse during the period of deep anesthesia and tachycardia at the time of awakening, but not a single case developed apnoea or Sinking of the root of a tonbue. Nausea and vomiting were recognized in 30%.
3. Of the side effects stated above, the injection of Ephedrine 1.0 cc or Neocinezine (No. 2) 0.5 cc immediately before phlebonarcosis could prevent the lowereing of the blood pressure and the administration of 2 tablets (4 mg) of PZC 60 minutes in advance could prevent the development of nausea of vomiting.
In view of the findings stated above, Isozol is considered to be an excellent preparation for short period phlebonarcosis which can be applied safely on the cases of artificial abortion, endometritis and curettement.
