Journal of The Showa Medical Association
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
Volume 20, Issue 1
Displaying 1-12 of 12 articles from this issue
  • Eiichi Matsuda, Yukio Ogino, Hirokazu Sunada
    1960 Volume 20 Issue 1 Pages 1-7
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    Following the use of Evipan-Na by Weese in 1932, studies on the drugs for short period phlebonarcosis have become quite active and a number of preparations have appeared for this purpose, Thiamylal Sodium (Isozol) is one of the drugs thus appeared. Stated in the following are the findings of the use of this drug on a total of 110 cases of artificial abortion, endometritis and curettement.
    1. The naccotic effect of Isozol was excellent through out all the cases administered. The appearance of narcotic effect was smooth by the administration of 0.21g in average and the period of narcosis was short being only 10.1 minutes in average.
    2. No serious side effects were recognized, but there was a general tendency of lowering the blood pressure, this however was mild.
    As for the pulse, there were a few cases of arythmic and intermittent pulse during the period of deep anesthesia and tachycardia at the time of awakening, but not a single case developed apnoea or Sinking of the root of a tonbue. Nausea and vomiting were recognized in 30%.
    3. Of the side effects stated above, the injection of Ephedrine 1.0 cc or Neocinezine (No. 2) 0.5 cc immediately before phlebonarcosis could prevent the lowereing of the blood pressure and the administration of 2 tablets (4 mg) of PZC 60 minutes in advance could prevent the development of nausea of vomiting.
    In view of the findings stated above, Isozol is considered to be an excellent preparation for short period phlebonarcosis which can be applied safely on the cases of artificial abortion, endometritis and curettement.
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  • Yasushi Watanabe
    1960 Volume 20 Issue 1 Pages 8-11
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    Radial paralysis occupies the highest incidence rate among the damage carr injury of the periphral nerves and ther were 15 cases of radial paralysis reported to the clinicc of the Departmentt of Orthopedica, Showa Medical during the past 5 years. Their causes were 5 cases of oppression or contusion, 5 cases of erronious injection, 3 cases of operational mistake and 2 cases of other causes.
    The present patient had a traffic accident and the fracture of the right humerus bone. He received the fixing by the use of the inside metal splint. But, when the gypsum bandage was removed, the patient complained of the radial paralysis. Upon removal of the scar, the radial nerve was found to lie embedded under the scar and there was no motility. And, moreover, the screw which was used in fixing the splint at the most proximal end was found to have penetrated through the trunk of the radial nerve at the point distal to its bifurcation into the musculus triceps brachil and the musculus intercostales. The radial paralysis disappeared on removal of thee screw.
    It is considered indispensable, therefore, to insure the absence of paralysis prior to and also on an early stage after such operation.
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  • Eisei Noguchi
    1960 Volume 20 Issue 1 Pages 12-22
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    As a step for the clarification of the mechanisms of the development of B group vitamin deficiency encountered while undergoing chemotherapy, especially, antibiotic treatment, investigations were made on the influence of anti-tuberculous drugs (INAH, PZA, SM and PAS) on the in vivo nicotinic acid metabolism.
    Previously, Zatman et al suspected the occurrence of competitive inhibition by INAH on the basis of its resemblance to nicotinic acid in chemical structure and proved this on animal experiments. This author also proved this competitive inhibition of nicotinic acid metabolism on clinical cases.
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  • Report II. Triangles occipitalis
    Goro Odajima, Kankichiro Osada, Toshio Kurihara
    1960 Volume 20 Issue 1 Pages 23-26
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    Hypophyseal triangles are the matter of great interest in human anatomy as well as in comprative anatomy. Stated in the following are the findings of the craniometric studies done on the dog.
    As the mean of ∠LPLO in ΔPLO of the dog was the largest at 68.2°±0.44, while the mean of ∠LPO was the smallest at 46.7°±0.49, they were different from the respective measurements of human being. And, as the mean of ∠PBO in ΔPOB was the largest at 99.6°±0.65, while the mean of ∠BPO was the smallest at 19.9°±0.22, the latter resembled to the mean human measurement of 19.4°± 0.12.
    On the other hand, the mean of ∠BPL in ΔPLB was the largest at 66.7°±0.57, while the mean of ∠PLB was the smallest at 2.3°±0.37 showing no resemblance to the respective measurements of human being.
    Namely, in the dog, the ΔPLB having ∠PLB as its vertical angle approaches to an equilateral triangle, while in the case of human being, it forms a high isosceles triangle having ∠PLB as its vertical angle.
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  • Ryuichi Nakagawa
    1960 Volume 20 Issue 1 Pages 27-50
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    In the present study, Disulfiram into the embryonating eggs of white Leghorn, and its toxicity as well as the histological changes produced in the thyroid gland, liver and kidney were investigated. The following results were obtained :
    1. Body weight of the embryo demonstrated a tendency to decrease.
    2. The amount of allantoic fluid reduced and this reduction was stronger when the concentration of Disulfiram added was lower.
    3. The amount of amniotic fluid increased on the 15th day of embryonation, while on the contrary, it decreased on the 18th day of embryonation. This decrease was more conspicuous on the embryos received the Disulfiram injection of lower concentrations.
    4. Disulfiram produced the hypertrophy of the thyroid and increased its weight as well.
    5. Histological investigation of the thyroid showed characteristic findings such as the degeneration of epithelial cells and enlargement of individual follicles.
    6. On histological investigation, necrgsis, cord dissociation of the liver cells and visceral hyperemia were recognized in the liver and moderate retrogressiv degeneration in the kidney.
    7. The action of Disulfiram on the chick embryo is probably similar to that of other antithyroid substances.
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  • Satoru Kanaki, Yuko Sekiya, Naohiko Takatama, Masao Nakajima, Isao Kim ...
    1960 Volume 20 Issue 1 Pages 51-65
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    The injection of cocarboxylase into embryonating eggs showed no influence on the development of embryos and on the excretion of pyruvic acid and non-protein N into the allantoic fluid. Vitamin B1 content of the allantoic fluid and of the liver, however, showed an evident increase.
    The injection of pentobarbital-Na caused an evident change in the pyruvic acid content of the allantoic fluid of embryos. The change produced in the content of pyruvic acid was restored by the joint administration of cocarboxylase approaching to the value of the control.
    ChE activity of the embyronal brain was increased by the administration of cocarboxylase in the former half period of the hatching.
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  • Yuko Sekiya, Satoru Kanaki, Isao Kimura, Bunji Suzuki, Akira Kubota, G ...
    1960 Volume 20 Issue 1 Pages 66-72
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    Stated in the following are the results of Nicotine injections made into embryonating eggs.
    The degree of depression of the freezing point of the allantoic fluid showed a tendency to increase, while the concentration and the quantity of the total N were reduced.
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  • Shigetsugu Yamaguchi, Toshio Kawakita, Masao Nakajima, Bunji Suzui, Ry ...
    1960 Volume 20 Issue 1 Pages 73-80
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    1. Desoxyephedrine was loaded on the developing eggs which were left to undergo hatching. Those received more than 10 mg of desoxyephedrine by injection failed to complete the course of hatching, while those received less than 5 mg could complete hatching though there were some deaths in the course.
    2. Growth of the embryo was disturbed in the latter stage of hatching and hydrops was observed to have developed in some embryos received more than 1 mg of desoxyephedrine.
    3. Excretion of allantoic fluid was somewhat disturbed by the loading of desoxyephedrine.
    4. When viewed by the amount of residual nitrogen excreted into the allantoic fluid, nitrogen metabolism was found to be generally inhibited on the embryos loaded with desoxyephedrine in comparison with their controls, and the amount of nitrogen excretion became smaller when a larger dose was loaded.
    5. Excretion of vitamin B1 into the allantoic fluid too showed a tendency to diminish by the loading of desoxyephedrine.
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  • Satoru Kanaki, Hiroshi Sato, Sango Bak
    1960 Volume 20 Issue 1 Pages 81-85
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    Linolic acid in combination with vitamin B6 was administered daily on rabbits for a period of 6 weeks and the results obtained were as follows :
    Cholesterol and lipoid phosphorus contents of the serum began to diminish from the end of the first week, but the latter was restored to its normal value by the end of 4 to 5 weeks.
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  • Ken Kitaura
    1960 Volume 20 Issue 1 Pages 86-98
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    In the present study, adult female mice received a subcutaneous injection of diethyl-paranitro-phenyl-thiophosphate (Parathion) and histopathological investigations were made on the skeletal muscles (femoral muscles) of their new born sucklings.
    Degenerative changes and those of circulatory disturbance observed on the striated musclefibers, namely, granuly, granular degeneration, vacuolar degeneration, colliquative degeneration segmentation, dissociation, swelling, thick and thine nuclear staing, vacuolization etc, were the strongest on the group received 16 mg of Parathion the sucklings of 1 to 7 days and the intensity of those changes diminished following the decrease in the dose administered. The damages caused by the via placental toxicity of Parathion on the skeletal muscles of sucklings were classified into 3 major categories of growth disturbance, degeneration and circulation disturbance. Degenerative changes and those of circulation disturbance were mostly in parallel to the dose of Parathion administered, while the changes of growth disturbance were not necessarily in accordance with the dosage.
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  • Shigeru Tanaka
    1960 Volume 20 Issue 1 Pages 99-107
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    A number of Shigella strains were examined of their H2S production and following results were obtained :
    1. Among the strains of genus Shigella, it was found that some produce H2S by the usual method of cultivation and some by the use of special method, while the others fail to produce any detectable amount of H2S.
    2. Therefore, Shigella may not always be excluded from H2S producing bacteria.
    3. No significant biochemical difference was recognized between the H2S producing and non-producing strains of Shigella.
    4. Shigella strains capable of strongly producing H2S dissociate an extremely small number of H2S strongly producing colonies, weakly producing ones and a large number of so-called non-producing colonies. On the contrary, the possibility of the dissociation of strongly producing colonies from H2S non-producing strains was also recognized.
    5. The ability of H2S production may be influenced by various factors such as the kind and concentration of the peptone used, kind of the broth, the concentration of sodium chloride, pH of the medium and further by the method of cultivation employed.
    6. Shigella strains have a tendency to diminish or lose their ability to produce H2S while undergoing subcultures and this character is variant depending on the strain used.
    7. When the production of H2S is discussed on Shigella strains, it is considered indispensable to describe on the medium and the method of cultivation etc. employed.
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1960 Volume 20 Issue 1 Pages 108-109
    Published: April 30, 1960
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
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