Journal of The Showa Medical Association
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
STUDIES ON THE HISTOGENESIS OF LUNG TUMOR IN MICE ORALLY ADMINISTERED WITH ISONICOTINIC ACID HYDRAZID (INH)
Akira Yasuno
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1961 Volume 20 Issue 11 Pages 1626-1639

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Abstract
The author conducted various investigations on the lung tumors induced in mice by oral administration of 0.25 per cent isonicotinic acid hydrazid (INH) histogenetically. The following, results were thus obtained.
1) Generally speaking, most of tumors were found on the pleural surface.
2) Inflammation and atelectasis showed no particular causative relations with the formation.
3) The majority of the lung tumors (adenoma) induced by administration of INH per os are considered to be alveolar epithelia origin.
4) Malignancy could not be confirmed in the present experiment up to 18th month.
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