Abstract
Following the administration of CCl4 on rats, or simultaneously, sodium glucuronate (Sod G) or glucuronolactone (GL) was administered on the same rats in order to know their influence on the glutathione (GSH) reduced by CCl4.
Following the successive subcutaneous injections of CCl4, the concentration of GSH in the blood, cerebrum and the liver showed a gradual increase. Successive administration of Sod G or GL after the administration of CCl4 could inhibit this increase in the concentration of GSH.
Subcutaneous injections of CCl4 repeated every other day produced the elevation of GSH concentration in the blood and the liver, and the combined administration of Sod G and GL could inhibit this elevation of GSH concentration.
Thus, from the standpoint of GSH metabolism, it was found that glucuronic acid influences on CCl4 and that Sod G and GL are different in the intensity of their influence depending on the organs examined and the method of their administration.
