Abstract
Blue globulin substance which has a marked fibrinolytic activity were isolated from 10 folds redistilled water diluted dog plasma by acetic acid precipitation at pH 5.9.
When blue globulin substance was injected to renal artery of rabbits, proteinuria, hematuria and cylinduria can be seen clinically. Diffuse glomerular nephritis was demonstrated histologically.
When rabbits were treated with large amounts of vitamin C intravenously before injection of globulin substances, rabbits were prevented from nephritis clinically and histologically.
Repeated injection of vitamin C to rabbits caused increase of 17-ketosteroids in urine with elevation of serum vitamin C levels.
After injection of blobulin substance to rabbits, there were increase of vitamin C excretion in the urine temporarily.
