Abstract
Aminosulfonic acid or its derivative such as 1-amino-2-oxy-propanesulfonic acid, 1-monomethyl-amino-2-oxy-propanesulfonic acid, 1-dimethylamino-2-oxy-propanesulfonic acid or the betaine of sulfonic acid was injected into the embryonating eggs either alone or in combination with nicotine and histological investigations were made on the heart, lung and the thyroid of the developing chick embryos for the observation of the influence of those preparations alone as well as the influence of their administration on the histological changes produced by nicotine. The results obtained were as follows:
Administration of aminosulfonic acid or its derivatives generally causes the cellular infiltration in the pericardium and the proliferation of connetive tissue cells in the myocardial blood vessels. Their administration in combination with nicotine inhibits the development of myocardial vacuolar degeneration which can be observed by the single administration of nicotine.
Generally, moderate cellular infiltration is recognized in the lung and the bronchus of the embryos received these substances. Formation of hydrops follows, moreover, the administration of the betaine of sulfonic acid or 1-dimethylamino-2-oxy-propanesulfonic acid. Their administration in combination with nicotine, however, results either in the alleviation or disappearance of such changes.
Generally, 1-amino-2-oxy-propanesulfonic acid and its derivatives cause the proliferation of newly formed cells around the follicular epithelium of the thyroid. This change is especially remarkable when 1-amino -2-oxy-propanesulfonic acid is used and, moreover, the administration of 1-monomethylamino-2-oxy-propanesulfonic acid invites the loosening of the epithelial cells. Loosening of the epithelial cells is also seen when the betaine of sulfonic acid or 1-monomethylamino-2-oxy-propanesulfonic acid is used in combination with nicotine, but the combinations of nicotine with other substances produce no such severe changes.
Namely, aminosulfonic acid and its derivatives generally produce similar histological changes on the homologous organs and there exists antagonism between those substances and nicotine.
