PATHOMORPHOLOGICAL ANALYSIS OF THE INFLUENCE OF ANOXIA ON THE LIVER

Abstract

1. In the present experiment, Naphtalene and Sodium-nitrite, which are known as methemoglobin forming poisons, were administered on rabbits either by subcutaneous or intraperitoneal injection, infusion into the stomach or by feeding the diet containing them in a daily dose of 1.0g/kg Naphtalene or 50-60mg/kg Sodium-nitrite for the observation of acute influence and both drugs in a daily dose of 0.3-0.1g/kg for the observation of chronic influence of anoxia on the liver.
2. First, the changes of circulation disturbance caused by the disorder of blood stream or blood components appear followed by the changes of vascular damage caused by the poor oxygen supply to the vascular wall. Then, the retrogressive changes appear in the cells by the combined influence of the changes of circulatory disturbance and vascular damage. When the retrogressive changes advance, they show destructive and colliquative changes finally resulting in the necrosis.
As reparative processes, further, and as the terminal picture of the organ, tissue sclerotic changes (fibrosis) or cirrhotic changes are also indicated.
3. The primary lesion of the intralobular necrosis of the liver is the central zone surrounding the central vein.
4. The selective circumscribed necrosis observed on a specific portion of the lobule is not of different pathogenesis. It is understood to be the lesion of the same pathogenesis only different in intensity and in the time of observation.
5. In addition, the reason why the lesion is recognized as the necrosis of the central zone inspite of the same object of immediate invasion (Glisson's capsule) is considered to be due to the special tissue construction of the liver causing the difference in the site of its morphological expression.