Abstract
1. In the present experiment, 300 pure bred mice of the strain dbr were always maintained and the spontaneous mammary cancer ditected among them was transplanted on the male mice of the same strain for the obse vation of the influence of hormone such as Enarmon or Parotin classifying the mice into 4 groups of the subcutaneous injection given 72 hours in advance, immediately after, 24 hours and 72 hours after tumor transplantation. Observation of this influence was made chiefly by the histopathological investigationof the growth of tumor, especially, in relation to the surrounding muscular tissues.
2. Tumors formed in the mice of the group received hormone injection immediatly after transplantation were the smallest in size being only one half of the control. This tumor was malignant and epithelial in nature and Parotin was found to show some inhibition against its growth.
3. As for the findings of muscular fibers, the mice received Enarmon were characterized by the atrophy or disappearance of the subcutaneous muscular layer, while hypertrophy and swelling were rather scarce. Moderate swelling of the muscular layer under the tumor (dorsal muscles) was recognized in 2 cases.
The mice received Parotin showed only mild changes mostly being hydropic ones accompanying loosening and mostly they belonged to the pseudohypertrophy.
4. As for vaculation, it is considered to be due to the hypoxic changes produced in the muscular fibers. The vacules were found to change from small ones to large ones and when advanced they showed colliquative changes and necrosis.
