Abstract
Stated in the following are the findings of the in vivo distribution of theophylline (TP) and theobromine (TB) in the chick embryos after an injection of 1.0 mg or 2.0 mg of the former or 2.0 mg of the latter into the developing eggs.
Allantoic fluid showed an evident increase following the administration of TP, while it shhwed a decrease in the case of TB.
Both substances are recovered in a high concentration from the allantoic fluid as well as from the amniotic fluid. The total quantity of TP and TB in the allantoic fluid, however, was always larger than that of the amniotic fluid.
After administration, both substances are distributed in the brain, liver, heart and kidney in a relatively high concentration, especially, TB concentration in the kidney is remarkably high.
Both TP and TB are easily excreted into the allantoic fluid.
