Abstract
A curve for the determination of Caeruloplasmin value was first prepared by the use of crystalline caeruloplasmin and its value was determined on the sera of various diseases.
1. Serum caeruloplasmin values of normal healthy individuals were 15-19 mg/dl.
2. Patients of anemia, malignant tumor, infectious diseases, rheumatic arthritis, pleurisy and pregnant women showed higher levels of serum caeruloplasmin, while those of Wilson's disease and chronic nephritis without accompanying infections and anemia showed lower levels.
3. Caeruloplasmin is said to occupy 90-95% of serum copper, but anemic serum did not show a definite ratio of serum caeruloplasmin and serum copper. In the majority of such cases, serum copper level is high in relation to the respective caeruloplasmin level.
