Abstract
Treatments of Habu-snake venom by various substances were made in vitro, and their influence on the toxicity of the venom was examined.
1) Urea and sodium salicylate had no influence on the hemolytic effect of the venom, but they inhibited the intracutaneous hemorrhage in rabbit induced by the venom subcutaneously given, and lowered the mortality of the mice intraperitoneally given with the venom.
2) Formaldehyde, thioglycollic acid and cysteine markedly inhibited the hemolysis and intracutaneous hemorrhage, and lowered the mortality of the mice.
3) Sodium dodecyl sulfate and guanidine hydrochloride exerted no influence on the effect of the venom.
4) Sodium glucuronate prevented only the hemorrhage very slightly.
Thus, the toxic actions of Habu-snake venom could be partially inactivated by means of the drug treatment in vitro.
