Abstract
The auther studied 21 patients of malignant tumor who had admission in the Showa Medical School Hospital in 2 years period from Oct. 1961 to Jul. 1963. They were treated with administration of massive Mitomycin-c in pre-operative or operation period. And auther tryed bone marrow transfusion in 17 patients who had leucopenia after the chemotherapy or radiation therapy for malignant tumors.
Effects were following: -
1) High frequency lung complication following pre-operativ massive treatment was found.
2) In some patients of massive treatment in operation, suture insufficiency of intestine or abdominal wall was found, and experiments of dog, showed that the suture insufficiency was certeinly the side effect of Mitomycin-c.
3) More effective treatment of leucopeny, after chemotherapy or radiationtherapy for malignant tumors was bone marrow transfusion than others. The transfusion into sternum gave beter effects than that into the elbowvein and leucocytes increased to the mormal level in 3-4 weeks. Cortisone was given in some cases without clear effects.
4) The experiments with homogeneus bone marrow transfusion in dogs showed the beter effects with marrow than with vein.
Cortison also gave no clear effects in the experimental transfusion in dogs.
