Abstract
Study was performed on the relationship of rate of hemolysis, partial oxygen pressure of arterial blood and the production of erythropoietin in the phenylhydrazine-treated rabbits to examine the influencing factor in erythropoietin production.
In the group showing rapid rate of hemolysis, the hemoglobin concentration, at the beginning of elevation erythropoietin, was lower than that of slow rate of hemolysis. However, increasing rate of erythropoietin activity revealed higher in the group of rapid hemolysis.
When the hemoglobin concentration reached down about 10 Gm/dl., the partial oxygen pressure of arterial blood began to decrease preceding the elevation of erythropoietic activity regardless the rate of hemolysis.
