低酸素症性変化を中心とした甲状腺の病理

抄録

In the present experiment, emulsion of diethyl-paranitro-phenyl-thiophosphate, which is an organic phosphate chemical (parathion) was subcutaneously injected into rabbits twice weekly. The animal were administered with a dose of 4 mg, 8 mg, 16 mg and 24 mg/kg of the emulsion. Histological changes of thyroid in the acute, subacute and chronic stages were studied up to 204 days.
1) The findings in the acute stage.
Mild vacuolar degeneration of the follicular epithelia and dark staining of intraluminal content were observed in these received 24 mg/kg. There were also decrease in staning grade and segmentation of arginophilic fiber of basement membrane, edematous swelling of stromal fiber and expansion with edema of interstitium.
2) The findings in the subacute stage.
Slight irregularity in size and atrophy of follicles, vacuolar degeneration of the epithelia were seen in those received a dose of 4-8 mg/kg. The changes of stromal and basic membrane fiber were similar to those in the acute stage.
3) The irregularity of follicle size, and atrophy and destruction of follicles were more significant, especially in those received 24 mg/kg. Desquamated epithelia and red blood cells were also recognized in the lumen, and the regressive changes were generally more conspicuous.
4) The findings in the chronic stage.
In the group received a small dose, the findings were similar to those in the subacute stage, and collid was found in the interstitium.
In the group received a large dose, both findings of follicle and interstitium resembled those in the subacute stage, with also slight round cell infiltration in the interstitial tissue and hemorrage inside or outside of the follicles. Destruction and atrophy were more marked, but on the other hand, repair and reconstruction were also observed.
5) Interstitial edema, and regressive changes, especially atrophy of follicles are important hypoxic change, but the proper toxic influence caused by parathion was presented as vascular lesions, making the entire pathological picture of the thyroid more complicated and severe.