ON THE STUDY OF HEMODYNAMIC CHANGES IN DUMPING SYNDROME

Abstract

The author studied hemodynamic changes and its relationship with bradyklnin like substance in blood in Dumping syndrome.
The results obtained as follows
1) The cases are divided into following four groups.
A group : 38 cases before gastrectomy
B group : 145 cases without any complaints after gastrectomy
C group : 11 cases with complaints except Dumping syndrome
D group : 57 cases with Dumping syndrome
The author measured circulatory serous volume in each group after test meal. The results showed that there are no change in group A, less decrease in group B, some decrease in group C, and much decrease in group D.
2) Analyzing these data in Dumping syndrome, it is reasonable to set R≥85 for decrease in the circulating serous volume.
3) In group C and D, great increase of the peipheral blood flow was observed by pletysmography. Especially in group D, maximum rate was obtained 30 min, later after meal.
4) The author studied SIR rate in relation between circulating serous volume and peripheral blood flow. No change was observed in group A and B, but some increase in group C with time was also observed. Maximum rate was obtained in group D 30 min, later after meal.
5) Maximum change in puls was obtained in group C (15 min, later after meal) and D (30 min, later after meal) .
6) In relation between circulating blood flow and puls, great change was noticed in group D.
7) On bradykinin like substance in blood, there are tendency of decrease in group B, however of increase in group D. This suggests that bradykinin like substance in blood takes great part in cause of Dumping syndrome.
8) In relation between bradykinin like substance and circulating serous volume, increase of the former makes decrease of the latter.
9) In relation between bradykinin like substance in blood and peripheral blood flow, there are no meaning statistically.
10) In relation between bradykinin like substance in blood and blood pressure, there are no meaning statistically.
11) In relation between bradykinin like substance in blood and puls, there are no meaning statistically.
As above mentioned, hemodynamic changes cause great effects in Dumping syndrome. There are decrease of circulating serous volume, blood pressure and increase of peripheral blood flow, and puls., however ther are some constant tendency in those changes. It became clear that bradykinin like substance in blood have great effects to the hemodynamic flow.