Abstract
It was reported recently that the extradural administration of Co-V.B12 (DBCC) was effective in treatment of various kinds of low back pain.
In this experiment, the effect of DBCC on the nerve conduction was investigated electrophysiologically in isolated rabbit nerve preparation to explore the genesis of therapeutic effect of this compound on the low back pain. For this purpose action potentials of ventral and of dorsal root caused by electric stimulation of sciatic nerve were observed under influence of DBCC, and following observations were made.
1. DBCC more selectively blooked conduction of dorsal root than that of ventral root.
2. Lower concentration of DBCC potentiates action potential.
3. Ventral root has higher threshold to DBCC than dorsal root. Therefore higher doses of DBCC blocked conduction of both ventral and dorsal roots, proper doses of it potentiate the action potential of ventral root and block that of dorsal root, and lower of it potentiate only dorsal root action potential. Those higher, proper, and lower doses of it were 0.5, 100, 500 γ/ml respectively.
Basing from these observations, 100, 250, and 500 γ/ml of DBCC were used for treatment of low back pain and following symptoms were observed for checking the effect of DBCC and for comparing above stated experimental results. Those are low back pain, leg raising test, hypesthesia, knee jerk reflex, Achilles tendon reflex, and muscle force.
As a result, following conclusion was obtained.
1. Extradural administration of DBCC is effective in treatment of low back pain.
2. Generally, the effective dose of DBCC for low back pain was 250 γ/ml. In the case of intense low back pain accompaning hypesthesia, 500 γ/ml of DBCC was more effective than 250 γ/ml, however in this case the moter function decreased transiently.
3. Those effects of DBCC did not appeare just after injection. For example, it appeared 40-60, 30 and 10-15 minutes after injection of 100, 250, and 500 γ/ml respectively.
4. No remarkable side effect was observed in extradural administration of DBCC.
