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Volume 32, Issue 6
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[in Japanese]1972 Volume 32 Issue 6 Pages 271-277
Published: June 28, 1972
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (1108K) -
Mithuyoshi Andou1972 Volume 32 Issue 6 Pages 278-291
Published: June 28, 1972
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIt was reported recently that the extradural administration of Co-V.B12 (DBCC) was effective in treatment of various kinds of low back pain.
In this experiment, the effect of DBCC on the nerve conduction was investigated electrophysiologically in isolated rabbit nerve preparation to explore the genesis of therapeutic effect of this compound on the low back pain. For this purpose action potentials of ventral and of dorsal root caused by electric stimulation of sciatic nerve were observed under influence of DBCC, and following observations were made.
1. DBCC more selectively blooked conduction of dorsal root than that of ventral root.
2. Lower concentration of DBCC potentiates action potential.
3. Ventral root has higher threshold to DBCC than dorsal root. Therefore higher doses of DBCC blocked conduction of both ventral and dorsal roots, proper doses of it potentiate the action potential of ventral root and block that of dorsal root, and lower of it potentiate only dorsal root action potential. Those higher, proper, and lower doses of it were 0.5, 100, 500 γ/ml respectively.
Basing from these observations, 100, 250, and 500 γ/ml of DBCC were used for treatment of low back pain and following symptoms were observed for checking the effect of DBCC and for comparing above stated experimental results. Those are low back pain, leg raising test, hypesthesia, knee jerk reflex, Achilles tendon reflex, and muscle force.
As a result, following conclusion was obtained.
1. Extradural administration of DBCC is effective in treatment of low back pain.
2. Generally, the effective dose of DBCC for low back pain was 250 γ/ml. In the case of intense low back pain accompaning hypesthesia, 500 γ/ml of DBCC was more effective than 250 γ/ml, however in this case the moter function decreased transiently.
3. Those effects of DBCC did not appeare just after injection. For example, it appeared 40-60, 30 and 10-15 minutes after injection of 100, 250, and 500 γ/ml respectively.
4. No remarkable side effect was observed in extradural administration of DBCC.View full abstractDownload PDF (1652K) -
Atsuo Hashimoto1972 Volume 32 Issue 6 Pages 292-296
Published: June 28, 1972
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe most striking feature of the infection with Hymenolepis nana is the fact that a tissue phase of infection, which takes place in direct cycle after eggs are fed to mice, ac-companies onset of a high degree of immunity against subsequent infection. Rabbit anti-mouse thymocyte serum (ATS) completely abolished the acquired immunity of primary infected mice against challenge infection with eggs of H. nana, when injected intraperitoneally on days -2, -1, 0, 1, 2 and 3 relative to initial infection. ATS apparently produced its immunosuppressive effect without reacting with mouse serum proteins as judged by immunoelectrophoresis. Rabbit anti-mouse lymphocyte serum (ALS) raised in response to cells from the spleen, thymus, thoracic node, mesenteric node and inguinal node could not produce such an immunosuppressive activity on the acquired immunity. Differences between ALS and ATS were discussed, especially from the viewpoint of preparation method of these two kinds of sera.
As mentioned above, the demonstration that the ATS enhances susceptibility in mice to H. nana seem to place the infection mechanism in the same category as others in which cellular immunity dominates over humoral effects.View full abstractDownload PDF (2067K) -
Kiyoshi Nakashita1972 Volume 32 Issue 6 Pages 297-306
Published: June 28, 1972
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe guinea pigs were provocated by the injection of 0.5 ml of 0.01% histamine solution and 0.5 ml of 0.01% bradykin in solution. I used Carlsson's method to study the changes of fluorescence in adrenal medulla and the wall of small arteries of the lung, heart and intestine. In adrenall medulla, no marked change of fluorescence of cetecholamine was recognized after injecting of histamin and bradykinin solution. In arteriale walls of the lung, the decrease of fluorescent intesity of noradrenaline were detected after the injection. Meanwhile, in the arteriale walls of intestine, the fluorescent intensity of noradrenaline was followed by little change after injection of histamine and bradykinin solution. In this experiment, I recognized that the fluorescent intensity in arteriale walls of the respiratory system was decreased, but in the digestive system, little change was detected in anaphylactic shock. The distribution of noradrenaline fluorescence in the coronary arteries was noticed to be different f roni other arteries.View full abstractDownload PDF (8690K)
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