Abstract
The effects of new antispasmodic drug, n-butoxybenzyl hyoscyamine bromide (BHB) on the motility of bile duct and small intestine of guinea pig or rabbit were examined.
1. Spontaneous contraction of the isolated bile duct was inhibited and tonus was. decreased by the administration of BHB at doses greater than 1×10-7g/ml. To provoke the spasmolytic effect, a dose of 1×10-6g/ml was necessary.
2. Spasmus provoked by acetylcholine and BaCh were inhibited by BHB. Antispasmodic action of BHB against the evoked spasm by BaC12 was stronger than that against. the spasm by acetylcholine.
3. The dose-response curves against the evoked contracture by acetylcholine and histamine and the antispasmoidic action of several antispasmodicus were shown in figures 2, 3 and 4.
