Abstract
1) 0.5 ml/kg of phenylhydrazine hydrochloride was injected subcutaneously into rabbits every three days at a concentration of 2%, 4% and 8%, respectively.
2) Edematous and colliquative changes in the malpighian tuft, swelling of Bowmann's capsule and pericapsular edema, vacuolar degeneration of the tubular epithelium and edema of the interstitium are related to hypoxemic change.
3) The ultramicroscopic findings observed in the A group (2% solution) showed an irregular arrangement of the mitochondrial christae in the proximal tubular epithelium, as represented by a partial disappearance of the christae.
4) The reddish homogenous lesion and colliquative change in the center of periphery of the Malpighian tuft appear to originate in the intercapillary region. Since these findings exceed the categoly of mesangial edema, such changes are best called intercapillary edema.
