甲状腺における化学的物質由来の病変について

抄録

Saponin with hemolytic action, 1, 4 and 8 mg/kg, was injected subctaneously in healthy rabbits every third day. Changes of hematological picture were studied in chronological sequence in groups of short, relatively long and long period of treatment, along with patho-ihistological studies on the thyroid.
Results:
1. As to the pathbhistological picture of the thyroid gland, congestion and edematous coarsening in the interstitium were always noted in each period and group. In the paren-chyma, a tendency towards atrophy, shrinkage and devastation was noted.
2. In the group treated with a low dose for a short period, scarcely any change of parenchyma was noted. Along with an increase of the dose, follicular atrophy, necrosis and degeneration of the epithelium, and a decrease or disappearance of colloid was noted.
3. In the group treated for a long time, the group treated with low concentration showed moderate decrease, thinning and disappearance of colloid, indicating an aggravation. In groups treated with moderate and high concentration, disappearance of colloid representsthe main change, accompanied by marked diffuse interstitial fibrosis and picture of reconstruction.
4. These hematological and pathohistological findings would indicate that administration of phenylhydrazine causes hemolytic anemia followed by hypoxia. Based on these changes, circulatory disturbance appears in the thyroid, especially edematous changes due to organ hypoxia. This causes disturbance of parenchyma along with injurious effect proper to phenylhydrazine. Along with the time course various disease pictures aggravate and become colorful, leading to deveastation but eventual repair.