Abstract
We investigated the effects of NKK-105, diisopropyl 4-hydroxy-1, 3-dithiolan-2-ylidene malonate (NKK-103), diisopropyl 1, 3-dithiolan-2-ylidene malonate (NKK-100), ursodeoxycholic acid (UDCA) and trithio-p-methoxy phenylpropene (TMPP) on the hepatic blood flow, bile flow and biliary components of Beagle dogs and Sprague-Dawlay rats. The results were as follows
1) NKK-105 showed little inhibitory effect on respiration, and lowering of blood pres-sure by about 20 mmHg in the dogs by a dose of 5.0 mg/kg, i.v..
2) NKK-105 (5.0 mg/kg, iv.) caused a significant increase in the quantity of hepatic blood flow and bile flow in the dogs. The similar effect was observed by the administration of NKK-103 and NKK-100. UDCA increased bile flow but had no effect on the hepatic blood flow. TMPP decreased hepatic blood flow but had little effect on the bile flow.
3) NKK-105 and NKK-103, when administered to rats, increased bile flow, but had no effect by administration of NKK-100.
4) An increase in the biliary bile acids, bilirubin and lipids concentration was observed after the i.v. administration of NKK-105, NKK-103, NKK-100 and UDCA in the dogs. TMPP increased the excretion of bilirubin markedly but had little effects on the bile acids and lipids.
5) NKK-105 and NKK-100 increased the excretion of bile acids, bilirubin and lipids in the bile components of rats. NKK-103 had no effects on the excretion of bile components of rats.
